The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

Iron is abundant universally. During the evolutionary processes, humans have selected iron
as a carrier of oxygen inside the body. However, iron works as a double‐edged sword, and …

Although proteolysis targeting chimeras (PROTACs) have become promising therapeutic
modalities, important concerns exist about the potential toxicity of the approach owing to …

The development of new therapeutic approaches to diseases relies on the identification of
key molecular targets involved in amplifying disease processes. One such molecule is …

Triple-negative breast cancers (TNBCs) are aggressive and lack targeted therapies.
Understanding how nutrients are used in TNBCs may provide new targets for therapeutic …

Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-
suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without …

Cutaneous melanoma is a common cancer and cases have steadily increased since the mid
70s. For some patients, early diagnosis and surgical removal of melanomas is lifesaving …

The thioredoxin system plays an important role in maintaining a reducing environment in the
cell. Recently, several thioredoxin binding partners have been identified and proposed to …

Identification of thioredoxin binding protein-2 (TBP-2), which is currently known as
thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) …

The apical junctional complex (AJC), composed of tight and adherens junctions, maintains
epithelial barrier function. Since cigarette smoking and chronic obstructive pulmonary …