Purpose Diabetic peripheral neuropathy (DPN) is the commonest cause of neuropathy
worldwide, and its prevalence increases with the duration of diabetes. It affects …

The incidence of both type 1 and type 2 diabetes is increasing worldwide. Diabetic
peripheral neuropathy (DPN) is among the most distressing and costly of all the chronic …

The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …

In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal
physiology and disease. Enabling the dissection of corneal architecture at a cellular level …

Diabetic peripheral neuropathy (DPN) is one of the most common long term complications of
diabetes. Corneal confocal microscopy (CCM) image analysis is a novel non-invasive …

There are potentially many ways of assessing diabetic peripheral neuropathy (DPN).
However, they do not fulfill US Food and Drug Administration (FDA) requirements in relation …

Diabetic neuropathy is associated with increased morbidity and mortality. To date, limited
data in subjects with impaired glucose tolerance and diabetes demonstrate nerve fiber …

OBJECTIVE The accurate quantification of human diabetic neuropathy is important to define
at-risk patients, anticipate deterioration, and assess new therapies. RESEARCH DESIGN …

Abstract Small-fibre neuropathy (SFN), a disorder of thinly myelinated Aδ-fibres and
unmyelinated C-fibres, is clinically characterized by neuropathic pain symptoms and …

We describe and evaluate an automated software tool for nerve-fiber detection and
quantification in corneal confocal microscopy (CCM) images, combining sensitive nerve …