The human reference genome is the most widely used resource in human genetics and is
due for a major update. Its current structure is a linear composite of merged haplotypes from …

Integration of genomic technology into healthcare settings establishes new capabilities to
predict disease susceptibility and optimize treatment regimes. Yet, Indigenous peoples …

Genome-wide association studies (GWAS) have laid the foundation for investigations into
the biology of complex traits, drug development and clinical guidelines. However, the …

A historical tendency to use European ancestry samples hinders medical genetics research,
including the use of polygenic scores, which are individual-level metrics of genetic risk. We …

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The vast majority of genome-wide association studies (GWASs) are performed in
Europeans, and their transferability to other populations is dependent on many factors (eg …

Recent studies have highlighted the imperatives of including diverse and under-represented
individuals in human genomics research and the striking gaps in attaining that inclusion …

Precision medicine is predicted to revolutionize the clinical practice of medicine, in part by
using molecular biomarkers to assess patients' risk, prognosis, and therapeutic response …

Despite repeated calls by scholars to critically engage with the concepts of race and
ethnicity in US epidemiologic research, the incorporation of these social constructs in …

Conducting genomic research in diverse populations has led to numerous advances in our
understanding of human history, biology, and health disparities, in addition to discoveries of …