Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …

Metabolomics is a nascent field of inquiry that emerged in the late 20 th century. It
encompasses the comprehensive profiling of metabolites across a spectrum of organisms …

NMR spectroscopy, one of the two major analytical platforms utilized in the metabolomics
field, has witnessed a large number of advances in fundamental studies, methods …

There is a dire need to discover new targets for Alzheimer's disease (AD) drug development.
Decreased neuronal glucose metabolism that occurs in AD brain could play a central role in …

Maple syrup urine disease (MSUD) is an autosomal recessive disorder caused by
decreased activity of the branched-chain α-ketoacid dehydrogenase complex (BCKDC) …

Disrupted brain metabolism is a critical component of several neurodegenerative diseases.
Energy metabolism of both neurons and astrocytes is closely connected to neurotransmitter …

The neurodegenerative disorder Huntington's disease (HD) is typically characterized by
extensive loss of striatal neurons and the midlife onset of debilitating and progressive …

Acute respiratory distress syndrome (ARDS) is associated with high mortality rates, which
are further exacerbated when accompanied by acute kidney injury (AKI). Presently, there is …

The pronounced cachexia (unexplained wasting) seen in Huntington's disease (HD)
patients suggests that metabolic dysregulation plays a role in HD pathogenesis, although …

Among the most studied diseases that affect the central nervous system are Parkinson's,
Alzheimer's, and Huntington's diseases, but the lack of effective biomarkers, accurate …