Conditioning of the immune system by the microbiome

DB Graham, RJ Xavier - Trends in Immunology, 2023‏ - cell.com
The human intestinal microbiome has coevolved with its host to establish a stable
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …

Critical role of the gut microbiota in immune responses and cancer immunotherapy

Z Li, W **ong, Z Liang, J Wang, Z Zeng, D Kołat… - Journal of Hematology & …, 2024‏ - Springer
The gut microbiota plays a critical role in the progression of human diseases, especially
cancer. In recent decades, there has been accumulating evidence of the connections …

Microbiome diversity protects against pathogens by nutrient blocking

F Spragge, E Bakkeren, MT Jahn, E BN Araujo… - Science, 2023‏ - science.org
The human gut microbiome plays an important role in resisting colonization of the host by
pathogens, but we lack the ability to predict which communities will be protective. We …

Resource competition predicts assembly of gut bacterial communities in vitro

PY Ho, TH Nguyen, JM Sanchez, BC DeFelice… - Nature …, 2024‏ - nature.com
Microbial community dynamics arise through interspecies interactions, including resource
competition, cross-feeding and pH modulation. The individual contributions of these …

A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases

Q Yan, S Li, Q Yan, X Huo, C Wang, X Wang, Y Sun… - Cell, 2024‏ - cell.com
The gut fungal community represents an essential element of human health, yet its
functional and metabolic potential remains insufficiently elucidated, largely due to the limited …

Statistically learning the functional landscape of microbial communities

A Skwara, K Gowda, M Yousef… - Nature ecology & …, 2023‏ - nature.com
Microbial consortia exhibit complex functional properties in contexts ranging from soils to
bioreactors to human hosts. Understanding how community composition determines …

Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia

E Montassier, GD Kitsios, JE Radder, Q Le Bastard… - Nature Medicine, 2023‏ - nature.com
Respiratory microbial dysbiosis is associated with acute respiratory distress syndrome
(ARDS) and hospital-acquired pneumonia (HAP) in critically ill patients. However, we lack …

Bifidobacteria metabolize lactulose to optimize gut metabolites and prevent systemic infection in patients with liver disease

MA Odenwald, H Lin, C Lehmann, NP Dylla… - Nature …, 2023‏ - nature.com
Progression of chronic liver disease is precipitated by hepatocyte loss, inflammation and
fibrosis. This process results in the loss of critical hepatic functions, increasing morbidity and …

[HTML][HTML] Fecal microbiota transplantation: Emerging applications in autoimmune diseases

R Yang, Z Chen, J Cai - Journal of Autoimmunity, 2023‏ - Elsevier
Both genetic susceptibility and environmental factors are important contributors to
autoimmune disease pathogenesis. As an environmental factor, the gut microbiome plays a …

Strategies for tailoring functional microbial synthetic communities

J **g, P Garbeva, JM Raaijmakers… - The ISME …, 2024‏ - academic.oup.com
Natural ecosystems harbor a huge reservoir of taxonomically diverse microbes that are
important for plant growth and health. The vast diversity of soil microorganisms and their …