Glutamate is a nonessential amino acid, a major bioenergetic substrate for proliferating
normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in …

The calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor that responds
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

Because of the low stoichiometry of protein phosphorylation, targeted enrichment prior to LC–
MS/MS analysis is still essential. The trend in phosphoproteome analysis is shifting toward …

1. Abstract Background Current concepts of Attention-Deficit/Hyperactivity Disorder (ADHD)
emphasize the role of higher-order cognitive functions and reinforcement processes …

Protein kinase C (PKC) is a family of enzymes whose members transduce a large variety of
cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids …

In motor neuron disease, the focus of therapy is to prevent or slow neuronal degeneration
with neuroprotective pharmacological agents; early diagnosis and treatment are thus …

Exquisitely tuned activity of protein kinase C (PKC) isozymes is essential to maintaining
cellular homeostasis. Whereas loss-of-function mutations are generally associated with …

Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

The limitations of classical drugs have spurred the development of covalently tethered
photoswitchable ligands to control neuromodulatory receptors. However, a major …