Progesterone actions and resistance in gynecological disorders
Estrogen and progesterone and their signaling mechanisms are tightly regulated to maintain
a normal menstrual cycle and to support a successful pregnancy. The imbalance of estrogen …
a normal menstrual cycle and to support a successful pregnancy. The imbalance of estrogen …
Physiological and molecular determinants of embryo implantation
S Zhang, H Lin, S Kong, S Wang, H Wang… - Molecular aspects of …, 2013 - Elsevier
Embryo implantation involves the intimate interaction between an implantation-competent
blastocyst and a receptive uterus, which occurs in a limited time period known as the …
blastocyst and a receptive uterus, which occurs in a limited time period known as the …
The association and significance of p53 in gynecologic cancers: the potential of targeted therapy
M Nakamura, T Obata, T Daikoku… - International Journal of …, 2019 - mdpi.com
Dysfunction of p53 is observed in the many malignant tumors. In cervical cancer, p53 is
inactivated by degradation through the complex with human papilloma virus (HPV) …
inactivated by degradation through the complex with human papilloma virus (HPV) …
KRAS activation and over-expression of SIRT1/BCL6 contributes to the pathogenesis of endometriosis and progesterone resistance
Endometriosis is an inflammatory condition that is associated with progesterone resistance
and cell proliferation, resulting in pain, infertility and pregnancy loss. We previously …
and cell proliferation, resulting in pain, infertility and pregnancy loss. We previously …
Proteome instability is a therapeutic vulnerability in mismatch repair-deficient cancer
Deficient DNA mismatch repair (dMMR) induces a hypermutator phenotype that can lead to
tumorigenesis; however, the functional impact of the high mutation burden resulting from this …
tumorigenesis; however, the functional impact of the high mutation burden resulting from this …
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis
AL Kennedy, JP Morton, I Manoharan, DM Nelson… - Molecular cell, 2011 - cell.com
Mutations in both RAS and the PTEN/PIK3CA/AKT signaling module are found in the same
human tumors. PIK3CA and AKT are downstream effectors of RAS, and the selective …
human tumors. PIK3CA and AKT are downstream effectors of RAS, and the selective …
Epidemiology of endometrial carcinoma: etiologic importance of hormonal and metabolic influences
AS Felix, HP Yang, DW Bell, ME Sherman - Molecular Genetics of …, 2017 - Springer
Endometrial carcinoma is the most common gynecologic cancer in developed nations, and
the annual incidence is projected to increase, secondary to the high prevalence of obesity, a …
the annual incidence is projected to increase, secondary to the high prevalence of obesity, a …
The genomics and genetics of endometrial cancer
AJ O'Hara, DW Bell - Advances in genomics and genetics, 2012 - Taylor & Francis
Most sporadic endometrial cancers (ECs) can be histologically classified as endometrioid,
serous, or clear cell. Each histotype has a distinct natural history, clinical behavior, and …
serous, or clear cell. Each histotype has a distinct natural history, clinical behavior, and …
Suppression of PI3K/Akt/mTOR/c-Myc/mtp53 positive feedback loop induces cell cycle arrest by dual PI3K/mTOR inhibitor PQR309 in endometrial cancer cell lines
Gene mutations in PIK3CA, PIK3R1, KRAS, PTEN, and PPP2R1A commonly detected in
type I endometrial cancer lead to PI3K/Akt/mTOR pathway activation. Bimiralisib (PQR309) …
type I endometrial cancer lead to PI3K/Akt/mTOR pathway activation. Bimiralisib (PQR309) …
The role of the inflammatory microenvironment in thyroid carcinogenesis
Immune responses against thyroid carcinomas have long been demonstrated and
associations between inflammatory microenvironment and thyroid carcinomas repeatedly …
associations between inflammatory microenvironment and thyroid carcinomas repeatedly …