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Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
Long noncoding RNAs in cancer metastasis
Metastasis is a major contributor to cancer-associated deaths. It is characterized by a
multistep process that occurs through the acquisition of molecular and phenotypic changes …
multistep process that occurs through the acquisition of molecular and phenotypic changes …
Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
Functional classification and experimental dissection of long noncoding RNAs
Over the last decade, it has been increasingly demonstrated that the genomes of many
species are pervasively transcribed, resulting in the production of numerous long noncoding …
species are pervasively transcribed, resulting in the production of numerous long noncoding …
Enhancer RNAs are an important regulatory layer of the epigenome
Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development
and disease through their regulation of transcription, RNA processing and translation …
and disease through their regulation of transcription, RNA processing and translation …
Long noncoding RNAs: molecular modalities to organismal functions
We have known for decades that long noncoding RNAs (lncRNAs) can play essential
functions across most forms of life. The maintenance of chromosome length requires an …
functions across most forms of life. The maintenance of chromosome length requires an …
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
INTRODUCTION The human genome contains tens of thousands of loci that produce long
noncoding RNAs (lncRNAs), transcripts that have no apparent protein-coding potential. A …
noncoding RNAs (lncRNAs), transcripts that have no apparent protein-coding potential. A …
Overcoming challenges and dogmas to understand the functions of pseudogenes
Pseudogenes are defined as regions of the genome that contain defective copies of genes.
They exist across almost all forms of life, and in mammalian genomes are annotated in …
They exist across almost all forms of life, and in mammalian genomes are annotated in …
Promoter of lncRNA gene PVT1 is a tumor-suppressor DNA boundary element
Noncoding mutations in cancer genomes are frequent but challenging to interpret. PVT1
encodes an oncogenic lncRNA, but recurrent translocations and deletions in human cancers …
encodes an oncogenic lncRNA, but recurrent translocations and deletions in human cancers …
[HTML][HTML] Exploring the mechanisms behind long noncoding RNAs and cancer
Over the past decade, long noncoding RNAs (lncRNAs) have been identified as significant
players in gene regulation. They are often differentially expressed and widely-associated …
players in gene regulation. They are often differentially expressed and widely-associated …