Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

A review on potential therapeutic targets for the treatment of leishmaniasis

SY Sheikh, F Hassan, D Shukla, S Bala, T Faruqui… - Parasitology …, 2024 - Elsevier
Leishmania, a protozoan parasite, is responsible for the occurrence of leishmaniasis, a
disease that is prevalent in tropical regions. Visceral Leishmaniasis (VL), also known as kala …

Emerging therapeutic targets for treatment of leishmaniasis

S Sundar, B Singh - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Parasitic diseases that pose a threat to human life include leishmaniasis–
caused by protozoan parasite Leishmania species. Existing drugs have limitations due to …

The root‐knot nematode effector MiPDI1 targets a stress‐associated protein (SAP) to establish disease in Solanaceae and Arabidopsis

J Zhao, J Mejias, M Quentin, Y Chen… - New …, 2020 - Wiley Online Library
Large amounts of effectors are secreted by the oesophageal glands of plant‐parasitic
nematodes, but their molecular mode of action remains largely unknown. We characterized …

Secretome Analysis and In Planta Expression of Salivary Proteins Identify Candidate Effectors from the Brown Planthopper Nilaparvata lugens

W Rao, X Zheng, B Liu, Q Guo, J Guo… - Molecular Plant …, 2019 - Am Phytopath Society
The brown planthopper (BPH), Nilaparvata lugens (Stål), is a phloem sap-feeding insect.
During feeding on rice plants, BPH secretes salivary proteins with potential effector …

An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania donovani …

MAA Khan, JQ Ami, K Faisal, R Chowdhury, P Ghosh… - Parasites & vectors, 2020 - Springer
Background Visceral leishmaniasis (VL) caused by dimorphic Leishmania species is a
parasitic disease with high socioeconomic burden in endemic areas worldwide. Sustaining …

Proteomic approach for identification and characterization of novel immunostimulatory proteins from soluble antigens of Leishmania donovani promastigotes

SK Gupta, BS Sisodia, S Sinha, K Hajela, S Naik… - …, 2007 - Wiley Online Library
Visceral leishmaniasis (VL) caused by Leishmania donovani is a major parasitic disease
prevalent in endemic regions of Bihar in India. In the absence of good chemotherapeutic …

Potential therapeutic targets shared between leishmaniasis and cancer

S Rashidi, C Fernández-Rubio, R Manzano-Román… - Parasitology, 2021 - cambridge.org
The association of leishmaniasis and malignancies in human and animal models has been
highlighted in recent years. The misdiagnosis of coexistence of leishmaniasis and cancer …

Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages

CXC Santos, BS Stolf, PVA Takemoto… - Journal of leukocyte …, 2009 - academic.oup.com
Macrophage infection by Leishmania parasite is prone to oxidative stress in a redox-
regulated way by protein disulfide isomerase which is closely associated to NADPH oxidase …

[HTML][HTML] Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA …

DC Fernandes, AHO Manoel, J Wosniak Jr… - Archives of biochemistry …, 2009 - Elsevier
Mechanisms regulating NADPH oxidase remain open and include the redox chaperone
protein disulfide isomerase (PDI). Here, we further investigated PDI effects on vascular …