The tumor microenvironment (TME) is composed of many different cellular and acellular
components that together drive tumor growth, invasion, metastasis, and response to …

The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …

The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

Spatial clustering, which shares an analogy with single-cell clustering, has expanded the
scope of tissue physiology studies from cell-centroid to structure-centroid with spatially …

Over the past decade, single-cell genomics technologies have allowed scalable profiling of
cell-type-specific features, which has substantially increased our ability to study cellular …

The capability to spatially explore RNA biology in formalin-fixed paraffin-embedded (FFPE)
tissues holds transformative potential for histopathology research. Here, we present …

Taking advantage of natural variation promotes our understanding of phenotypic diversity
and trait evolution, ultimately accelerating plant breeding, in which the identification of …

Since the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell
analysis has become a powerful tool for exploration of cellular networks and dysregulated …

Spatial regulation of RNA plays a critical role in gene expression regulation and cellular
function. Understanding spatially resolved RNA dynamics and translation is vital for bringing …

Protein–RNA interactions are central to all RNA processing events, with pivotal roles in the
regulation of gene expression and cellular functions. Dysregulation of these interactions has …