Early intervention in psychosis: obvious, effective, overdue

PD McGorry - The Journal of nervous and mental disease, 2015 - journals.lww.com
Early intervention for potentially serious disorder is a fundamental feature of healthcare
across the spectrum of physical illness. It has been a major factor in the reductions in …

Cultures for mental health care of young people: an Australian blueprint for reform

PD McGorry, SD Goldstone, AG Parker… - The Lancet …, 2014 - thelancet.com
Mental ill health is now the most important health issue facing young people worldwide. It is
the leading cause of disability in people aged 10–24 years, contributing 45% of the overall …

Designing and scaling up integrated youth mental health care

PD McGorry, C Mei, A Chanen, C Hodges… - World …, 2022 - Wiley Online Library
Mental ill‐health represents the main threat to the health, survival and future potential of
young people around the world. There are indications that this is a rising tide of vulnerability …

Comparison of early intervention services vs treatment as usual for early-phase psychosis: a systematic review, meta-analysis, and meta-regression

CU Correll, B Galling, A Pawar, A Krivko… - JAMA …, 2018 - jamanetwork.com
Importance The value of early intervention in psychosis and allocation of public resources
has long been debated because outcomes in people with schizophrenia spectrum disorders …

Schizophrenia outcomes in the 21st century: a systematic review

P Huxley, A Krayer, R Poole, L Prendergast… - Brain and …, 2021 - Wiley Online Library
Objective We report a review of outcomes in schizophrenia in the twenty‐first century,
replicating and extending work undertaken by the late Richard Warner in his seminal …

Predictors of treatment-resistant and clozapine-resistant schizophrenia: a 12-year follow-up study of first-episode schizophrenia-spectrum disorders

SKW Chan, HYV Chan, WG Honer… - Schizophrenia …, 2021 - academic.oup.com
Studies on the long-term development and early predictors of treatment-resistant
schizophrenia (TRS) and clozapine-resistant TRS (CR-TRS) in patients with first-episode …

Long-term effects of discontinuation from antipsychotic maintenance following first-episode schizophrenia and related disorders: a 10 year follow-up of a randomised …

CLM Hui, WG Honer, EHM Lee, WC Chang… - The Lancet …, 2018 - thelancet.com
Background The long-term consequences of discontinuing antipsychotic medication after
successful treatment of first-episode psychosis are not well studied. We assess the relation …

A systematic review and meta-analysis of suicidality in psychotic disorders: Stratified analyses by psychotic subtypes, clinical setting and geographical region

A Álvarez, A Guàrdia, A González-Rodríguez… - Neuroscience & …, 2022 - Elsevier
We studied the prevalence of suicide attempts and cumulative incidence of completed
suicide in schizophrenia (SZ), schizoaffective disorder (SZAF), delusional disorder (DD) and …

The predictive power of expressed emotion and its components in relapse of schizophrenia: a meta-analysis and meta-regression

CF Ma, SKW Chan, YL Chung, SM Ng… - Psychological …, 2021 - cambridge.org
BackgroundSchizophrenia is a longstanding condition and most patients experience
multiple relapse in the course of the condition. High expressed emotion (HEE) has been …

Self-harm and suicide rates before and after an early intervention program for patients with first-episode schizophrenia

Y Chai, JYM Tang, DCF Ma, H Luo… - JAMA network …, 2024 - jamanetwork.com
Importance Evidence on the association of early intervention services (EISs) with self-harm
and suicide among patients with first-episode schizophrenia (FES) at older than 25 years is …