The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Inflammation and oxidative stress are common and co-substantial pathological processes
accompanying, promoting, and even initiating numerous cancers. The canonical WNT/β …

Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

As a main digestive organ and an important immune organ, the intestine plays a vital role in
resisting the invasion of potential pathogens into the body. Intestinal immune dysfunction …

The incidence of inflammatory bowel diseases (IBD) worldwide has resulted in a global
public health challenge. Intestinal fibrosis leading to stricture formation and bowel …

Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can
occur 4 to 12 months after radiation therapy. This process worsens with time and years …

Intestinal fibrosis is considered an inevitable complication of Crohn's disease (CD) that
results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment …

Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel
disease (IBD) and other inflammatory conditions, but while their involvement is clear, their …

The remodeling of extracellular matrix (ECM) within the intestine tissues, which
simultaneously involves an increased degradation of ECM components and excessive …

Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory
and oncology indications, including ulcerative colitis and colorectal cancer. MMP9 is a …