Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm
Multiple RNA pathways are required to produce functional sperm. Here, we review RNA post-
transcriptional regulation during spermatogenesis with particular emphasis on the role of …
transcriptional regulation during spermatogenesis with particular emphasis on the role of …
[HTML][HTML] Prenatal and postnatal exposure to polystyrene microplastics induces testis developmental disorder and affects male fertility in mice
Polystyrene microplastics (PS-MPs) can threaten human health, especially male fertility.
However, most existing studies have focused on the adulthood stage of male reproduction …
However, most existing studies have focused on the adulthood stage of male reproduction …
Establishing and maintaining fertility: the importance of cell cycle arrest
Abstract Development of the ovary or testis is required to establish reproductive
competence. Gonad development relies on key cell fate decisions that occur early in …
competence. Gonad development relies on key cell fate decisions that occur early in …
RNA‐binding protein ELAVL2 plays post‐transcriptional roles in the regulation of spermatogonia proliferation and apoptosis
C Yang, C Yao, Z Ji, L Zhao, H Chen, P Li… - Cell …, 2021 - Wiley Online Library
Objectives RNA‐binding proteins (RBPs) play essential post‐transcriptional roles in
regulating spermatogonial stem cells (SSCs) maintenance and differentiation. We identified …
regulating spermatogonial stem cells (SSCs) maintenance and differentiation. We identified …
The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation
MM Duszczyk, H Wischnewski, T Kazeeva… - Nature …, 2022 - nature.com
Dead End (DND1) is an RNA-binding protein essential for germline development through its
role in post-transcriptional gene regulation. The molecular mechanisms behind selection …
role in post-transcriptional gene regulation. The molecular mechanisms behind selection …
Early gonadal development and sex determination in mammal
Y **e, C Wu, Z Li, Z Wu, L Hong - International Journal of Molecular …, 2022 - mdpi.com
Sex determination is crucial for the transmission of genetic information through generations.
In mammal, this process is primarily regulated by an antagonistic network of sex-related …
In mammal, this process is primarily regulated by an antagonistic network of sex-related …
Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos
KJ Westerich, S Reinecke, J Emich… - Human …, 2023 - academic.oup.com
STUDY QUESTION Is the vertebrate protein Dead end (DND1) a causative factor for human
infertility and can novel in vivo assays in zebrafish help in evaluating this? SUMMARY …
infertility and can novel in vivo assays in zebrafish help in evaluating this? SUMMARY …
Instructing mouse germ cells to adopt a female fate
Background: Germ cells are critical for the survival of our species. They are the only cells
that undergo meiosis–the reductive form of cell division that is necessary for genetic …
that undergo meiosis–the reductive form of cell division that is necessary for genetic …
Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testes
A Imai, K Matsuda, Y Niimi, A Suzuki - Scientific Reports, 2023 - nature.com
Spontaneous testicular teratomas (STTs) are tumours comprising a diverse array of cell and
tissue types, which are derived from pluripotent stem-like cells called embryonal carcinoma …
tissue types, which are derived from pluripotent stem-like cells called embryonal carcinoma …
A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells
VA Ruthig, T Yokonishi, MB Friedersdorf… - Biology of …, 2021 - academic.oup.com
In vertebrates, the RNA-binding protein (RBP) dead end 1 (DND1) is essential for primordial
germ cell (PGC) survival and maintenance of cell identity. In multiple species, Dnd1 loss or …
germ cell (PGC) survival and maintenance of cell identity. In multiple species, Dnd1 loss or …