Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm

M Morgan, L Kumar, Y Li, M Baptissart - Cellular and Molecular Life …, 2021 - Springer
Multiple RNA pathways are required to produce functional sperm. Here, we review RNA post-
transcriptional regulation during spermatogenesis with particular emphasis on the role of …

[HTML][HTML] Prenatal and postnatal exposure to polystyrene microplastics induces testis developmental disorder and affects male fertility in mice

T Zhao, L Shen, X Ye, G Bai, C Liao, Z Chen… - Journal of Hazardous …, 2023 - Elsevier
Polystyrene microplastics (PS-MPs) can threaten human health, especially male fertility.
However, most existing studies have focused on the adulthood stage of male reproduction …

Establishing and maintaining fertility: the importance of cell cycle arrest

ER Frost, G Taylor, MA Baker… - Genes & …, 2021 - genesdev.cshlp.org
Abstract Development of the ovary or testis is required to establish reproductive
competence. Gonad development relies on key cell fate decisions that occur early in …

RNA‐binding protein ELAVL2 plays post‐transcriptional roles in the regulation of spermatogonia proliferation and apoptosis

C Yang, C Yao, Z Ji, L Zhao, H Chen, P Li… - Cell …, 2021 - Wiley Online Library
Objectives RNA‐binding proteins (RBPs) play essential post‐transcriptional roles in
regulating spermatogonial stem cells (SSCs) maintenance and differentiation. We identified …

The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation

MM Duszczyk, H Wischnewski, T Kazeeva… - Nature …, 2022 - nature.com
Dead End (DND1) is an RNA-binding protein essential for germline development through its
role in post-transcriptional gene regulation. The molecular mechanisms behind selection …

Early gonadal development and sex determination in mammal

Y **e, C Wu, Z Li, Z Wu, L Hong - International Journal of Molecular …, 2022 - mdpi.com
Sex determination is crucial for the transmission of genetic information through generations.
In mammal, this process is primarily regulated by an antagonistic network of sex-related …

Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos

KJ Westerich, S Reinecke, J Emich… - Human …, 2023 - academic.oup.com
STUDY QUESTION Is the vertebrate protein Dead end (DND1) a causative factor for human
infertility and can novel in vivo assays in zebrafish help in evaluating this? SUMMARY …

Instructing mouse germ cells to adopt a female fate

C Spiller, J Bowles - Sexual Development, 2023 - karger.com
Background: Germ cells are critical for the survival of our species. They are the only cells
that undergo meiosis–the reductive form of cell division that is necessary for genetic …

Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testes

A Imai, K Matsuda, Y Niimi, A Suzuki - Scientific Reports, 2023 - nature.com
Spontaneous testicular teratomas (STTs) are tumours comprising a diverse array of cell and
tissue types, which are derived from pluripotent stem-like cells called embryonal carcinoma …

A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells

VA Ruthig, T Yokonishi, MB Friedersdorf… - Biology of …, 2021 - academic.oup.com
In vertebrates, the RNA-binding protein (RBP) dead end 1 (DND1) is essential for primordial
germ cell (PGC) survival and maintenance of cell identity. In multiple species, Dnd1 loss or …