Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia

E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies

K Giusto, H Wanczyk, T Jensen… - Disease Models & …, 2021 - journals.biologists.com
Bronchopulmonary dysplasia (BPD) is a chronic lung disease caused by exposure to high
levels of oxygen (hyperoxia) and is the most common complication that affects preterm …

Sex and gender differences in lung disease

P Silveyra, N Fuentes, DE Rodriguez Bauza - Lung Inflammation in Health …, 2021 - Springer
Sex differences in the anatomy and physiology of the respiratory system have been widely
reported. These intrinsic sex differences have also been shown to modulate the …

[HTML][HTML] Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia

D Hirani, CM Alvira, S Danopoulos… - European …, 2022 - Eur Respiratory Soc
Rationale Premature infants exposed to oxygen are at risk for bronchopulmonary dysplasia
(BPD), which is characterised by lung growth arrest. Inflammation is important, but the …

Hyperoxia and lungs: what we have learned from animal models

L Amarelle, L Quintela, J Hurtado, L Malacrida - Frontiers in medicine, 2021 - frontiersin.org
Although oxygen (O2) is essential for aerobic life, it can also be an important source of
cellular damage. Supra-physiological levels of O2 determine toxicity due to exacerbated …

[HTML][HTML] Recent advances in understanding and management of bronchopulmonary dysplasia

M Sahni, V Bhandari - F1000Research, 2020 - ncbi.nlm.nih.gov
In the current era, the survival of extremely low-birth-weight infants has increased
considerably because of new advances in technology; however, these infants often develop …

Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles alleviate lung injury in rat model of bronchopulmonary dysplasia by affecting cell …

J You, O Zhou, J Liu, W Zou, L Zhang… - Stem cells and …, 2020 - liebertpub.com
Bronchopulmonary dysplasia (BPD) is a serious chronic lung disease in premature
newborns, with high morbidity and mortality rates. Mesenchymal stem cell (MSC) …

Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice

F Al-Mudares, M Cantu Gutierrez… - … of Physiology-Lung …, 2023 - journals.physiology.org
Growth differentiation factor 15 (GDF15) is a divergent member of the transforming growth
factor-β (TGF-β) superfamily, and its expression increases under various stress conditions …

[HTML][HTML] Effect of sex chromosomes versus hormones in neonatal lung injury

SL Grimm, X Dong, Y Zhang, AF Carisey, AP Arnold… - JCI insight, 2021 - ncbi.nlm.nih.gov
The main mechanisms underlying sexually dimorphic outcomes in neonatal lung injury are
unknown. We tested the hypothesis that hormone-or sex chromosome–mediated …

Intranasal delivery of human umbilical cord Wharton's jelly mesenchymal stromal cells restores lung alveolarization and vascularization in experimental …

A Moreira, C Winter, J Joy, L Winter… - Stem cells …, 2020 - academic.oup.com
Bronchopulmonary dysplasia (BPD) is a devastating lung condition that develops in
premature newborns exposed to prolonged mechanical ventilation and supplemental …