Systemic type 2 inflammation encompassing T helper 2 (TH2)-type responses is emerging
as a unifying feature of both classically defined allergic diseases, such as asthma, and a …

The gastrointestinal epithelium is covered by a protective mucus gel composed
predominantly of mucin glyco-proteins that are synthesized and secreted by goblet cells …

Summary Interleukin-10 (IL-10) affects the growth and differentiation of many hemopoietic
cells in vitro; in particular, it is a potent suppressor of macrophage and T cell functions. In IL …

Gamma interferon (IFN-γ) and B cell stimulatory factor-1 (BSF-1), also known as interleukin-
4, are T cell-derived lymphokines that have potent effects on B cell proliferation and …

Abstract INTERLEUKIN-4 (IL-4) is a pleiotropic lymphokine which plays an important role in
the immune system1. IL-4 activates two distinct signalling pathways through tyrosine …

T lymphocytes are the central regulatory cells of the immune system. Much of their function is
mediated by a set of small proteins whose expression, secretion, or both is induced as a …

Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor
alpha (TNF-alpha) when these cells are triggered with lipopolysaccharide and other …

Recently the cDNA encoding interleukin 13 (IL-13), a T-cell-derived cytokine, was cloned
and expressed. The present study demonstrates that IL-13 induces IgG4 and IgE synthesis …

We purified poly (A)+ mRNA from the spleen and lymph nodes at designated times after
infection with Leishmania major in genetically susceptible BALB/c and resistant C57BL/6 …

T cell populations derived from naive mice produce very small amounts of interleukin 4 (IL-4)
in response to stimulation on anti-CD3-coated dishes. IL-4 production by such cells is mainly …