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The reciprocal interactions between microglia and T cells in Parkinson's disease: a double-edged sword
Y Xu, Y Li, C Wang, T Han, H Liu, L Sun, J Hong… - Journal of …, 2023 - Springer
In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are
overactivated. Overactivation of these immune cells exacerbates the disease process and …
overactivated. Overactivation of these immune cells exacerbates the disease process and …
[HTML][HTML] T helper cells: the modulators of inflammation in multiple sclerosis
M Kunkl, S Frascolla, C Amormino, E Volpe, L Tuosto - Cells, 2020 - mdpi.com
Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by the
progressive loss of axonal myelin in several areas of the central nervous system (CNS) that …
progressive loss of axonal myelin in several areas of the central nervous system (CNS) that …
Priming of microglia with IFN‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects
J Zhang, H He, Y Qiao, T Zhou, H He, S Yi, L Zhang… - Glia, 2020 - Wiley Online Library
Neuroinflammation driven by interferon‐gamma (IFN‐γ) and microglial activation has been
linked to neurological disease. However, the effects of IFN‐γ‐activated microglia on …
linked to neurological disease. However, the effects of IFN‐γ‐activated microglia on …
[HTML][HTML] The involvement of neuroinflammation in the onset and progression of Parkinson's disease
A Jurcau, FL Andronie-Cioara… - International Journal of …, 2023 - mdpi.com
Parkinson's disease is a neurodegenerative disease exhibiting the fastest growth in
incidence in recent years. As with most neurodegenerative diseases, the pathophysiology is …
incidence in recent years. As with most neurodegenerative diseases, the pathophysiology is …
Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases
T Chen, Y Dai, C Hu, Z Lin, S Wang, J Yang… - Fluids and Barriers of …, 2024 - Springer
Background Maintaining the structural and functional integrity of the blood–brain barrier
(BBB) is vital for neuronal equilibrium and optimal brain function. Disruptions to BBB …
(BBB) is vital for neuronal equilibrium and optimal brain function. Disruptions to BBB …
Human in vivo evidence of reduced astrocyte activation and neuroinflammation in patients with treatment‐resistant depression following electroconvulsive therapy
Aim The current study aimed to investigate the neuroinflammatory hypothesis of depression
and the potential anti‐inflammatory effect of electroconvulsive therapy (ECT) in vivo, utilizing …
and the potential anti‐inflammatory effect of electroconvulsive therapy (ECT) in vivo, utilizing …
Astrocytes and inflammatory T helper cells: a dangerous liaison in multiple sclerosis
Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder of the central nervous
system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly …
system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly …
RANK/RANKL/OPG signaling in the brain: a systematic review of the literature
Together with its dominant immunological and bone remodeling involvement, RRO axis,
comprising of receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL), and …
comprising of receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL), and …
[HTML][HTML] Progress in research on TLR4-mediated inflammatory response mechanisms in brain injury after subarachnoid hemorrhage
L Wang, G Geng, T Zhu, W Chen, X Li, J Gu, E Jiang - Cells, 2022 - mdpi.com
Subarachnoid hemorrhage (SAH) is one of the common clinical neurological emergencies.
Its incidence accounts for about 5–9% of cerebral stroke patients. Even surviving patients …
Its incidence accounts for about 5–9% of cerebral stroke patients. Even surviving patients …
[HTML][HTML] Anti-idiotypic mRNA vaccine to treat autoimmune disorders
SK Niazi - Vaccines, 2023 - mdpi.com
The 80+ existing autoimmune disorders (ADs) affect billions with little prevention or
treatment options, except for temporary symptomatic management, leading to enormous …
treatment options, except for temporary symptomatic management, leading to enormous …