The reciprocal interactions between microglia and T cells in Parkinson's disease: a double-edged sword

Y Xu, Y Li, C Wang, T Han, H Liu, L Sun, J Hong… - Journal of …, 2023 - Springer
In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are
overactivated. Overactivation of these immune cells exacerbates the disease process and …

[HTML][HTML] T helper cells: the modulators of inflammation in multiple sclerosis

M Kunkl, S Frascolla, C Amormino, E Volpe, L Tuosto - Cells, 2020 - mdpi.com
Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by the
progressive loss of axonal myelin in several areas of the central nervous system (CNS) that …

Priming of microglia with IFN‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects

J Zhang, H He, Y Qiao, T Zhou, H He, S Yi, L Zhang… - Glia, 2020 - Wiley Online Library
Neuroinflammation driven by interferon‐gamma (IFN‐γ) and microglial activation has been
linked to neurological disease. However, the effects of IFN‐γ‐activated microglia on …

[HTML][HTML] The involvement of neuroinflammation in the onset and progression of Parkinson's disease

A Jurcau, FL Andronie-Cioara… - International Journal of …, 2023 - mdpi.com
Parkinson's disease is a neurodegenerative disease exhibiting the fastest growth in
incidence in recent years. As with most neurodegenerative diseases, the pathophysiology is …

Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases

T Chen, Y Dai, C Hu, Z Lin, S Wang, J Yang… - Fluids and Barriers of …, 2024 - Springer
Background Maintaining the structural and functional integrity of the blood–brain barrier
(BBB) is vital for neuronal equilibrium and optimal brain function. Disruptions to BBB …

Human in vivo evidence of reduced astrocyte activation and neuroinflammation in patients with treatment‐resistant depression following electroconvulsive therapy

S Xu, X **e, L Yao, W Wang, H Zhang… - Psychiatry and …, 2023 - Wiley Online Library
Aim The current study aimed to investigate the neuroinflammatory hypothesis of depression
and the potential anti‐inflammatory effect of electroconvulsive therapy (ECT) in vivo, utilizing …

Astrocytes and inflammatory T helper cells: a dangerous liaison in multiple sclerosis

M Kunkl, C Amormino, V Tedeschi, MT Fiorillo… - Frontiers in …, 2022 - frontiersin.org
Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder of the central nervous
system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly …

RANK/RANKL/OPG signaling in the brain: a systematic review of the literature

A Glasnović, N O'Mara, N Kovačić, D Grčević… - Frontiers in …, 2020 - frontiersin.org
Together with its dominant immunological and bone remodeling involvement, RRO axis,
comprising of receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL), and …

[HTML][HTML] Progress in research on TLR4-mediated inflammatory response mechanisms in brain injury after subarachnoid hemorrhage

L Wang, G Geng, T Zhu, W Chen, X Li, J Gu, E Jiang - Cells, 2022 - mdpi.com
Subarachnoid hemorrhage (SAH) is one of the common clinical neurological emergencies.
Its incidence accounts for about 5–9% of cerebral stroke patients. Even surviving patients …

[HTML][HTML] Anti-idiotypic mRNA vaccine to treat autoimmune disorders

SK Niazi - Vaccines, 2023 - mdpi.com
The 80+ existing autoimmune disorders (ADs) affect billions with little prevention or
treatment options, except for temporary symptomatic management, leading to enormous …