Immunoglobulins (Ig) play an important role in the immune system both when expressed as
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …

High-throughput sequencing of B-cell immunoglobulin repertoires is increasingly being
applied to gain insights into the adaptive immune response in healthy individuals and in …

Conventional immunization strategies will likely be insufficient for the development of a
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …

The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high
levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which …

Background We describe the genome of the western painted turtle, Chrysemys picta bellii,
one of the most widespread, abundant, and well-studied turtles. We place the genome into a …

Comprehensive knowledge of immunoglobulin genetics is required to advance our
understanding of B cell biology. Validated immunoglobulin variable (V) gene databases are …

The newly emerging Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes a
Severe Acute Respiratory Syndrome-like disease with∼ 43% mortality. Given the recent …

Obtaining full-length antibody heavy-and light-chain variable regions from individual B cells
at scale remains a challenging problem. Here we use high-throughput single-cell B-cell …

Individual variation in germline and expressed B-cell immunoglobulin (Ig) repertoires has
been associated with aging, disease susceptibility, and differential response to infection and …

IGHV polymorphism provides a rich source of humoral immune system diversity. One
important example is the IGHV1-69 germline gene where the biased use of alleles that …