Safety and tolerability of monoclonal antibodies targeting the CGRP pathway and gepants in migraine prevention: A systematic review and network meta-analysis

R Messina, EM Huessler, F Puledda… - …, 2023 - journals.sagepub.com
Background Direct comparisons of the tolerability and safety of migraine preventive
treatments targeting the calcitonin gene-related peptide pathway are lacking. This study …

A sco** review and meta-analysis of anti-CGRP monoclonal antibodies: predicting response

JB Hong, KS Lange, LH Overeem, P Triller, B Raffaelli… - Pharmaceuticals, 2023 - mdpi.com
Calcitonin gene-related peptide-targeted monoclonal antibodies (CGRP mAbs) are
increasingly being used as preventive treatments for migraine. Their effectiveness and …

Clinical evaluation of super-responders vs. non-responders to CGRP (-receptor) monoclonal antibodies: a real-world experience

B Raffaelli, M Fitzek, LH Overeem, E Storch… - The Journal of …, 2023 - Springer
Background Clinical trials and real-world studies revealed a spectrum of response to CGRP
(-receptor) monoclonal antibodies (mAbs) in migraine prophylaxis, ranging from no effect at …

Monoclonal antibodies against calcitonin gene-related peptide for migraine prophylaxis: a systematic review of real-world data

AR Pavelic, C Wöber, F Riederer, K Zebenholzer - Cells, 2022 - mdpi.com
Objective: To perform a systematic review of real-world outcomes for anti-CGRP-mAbs.
Methods: Following the PRISMA guidelines, we searched PubMed for real-world data of …

New migraine prophylactic drugs: Current evidence and practical suggestions for non-responders to prior therapy

MJ Lee, MAM Al-Karagholi, U Reuter - Cephalalgia, 2023 - journals.sagepub.com
Background Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its
receptor (anti-CGRP (-R) mAbs) and small-molecule CGRP receptor antagonists (gepants) …

Ten open questions in migraine prophylaxis with monoclonal antibodies blocking the calcitonin-gene related peptide pathway: a narrative review

J Schoenen, A Van Dycke, J Versijpt… - The Journal of Headache …, 2023 - Springer
The monoclonal antibodies (mAbs) blocking the calcitonin-gene related peptide (CGRP)
pathway, collectively called here “anti-CGRP/rec mAbs”, have dramatically improved …

Real-world evidence on the economic implications of CGRP-mAbs as preventive treatment of migraine

N Siersbæk, L Kilsdal, C Jervelund, S Antic… - BMC neurology, 2023 - Springer
Background Calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) are
approved in Europe as preventive treatment of migraine in patients with at least four monthly …

The Registry for Migraine (REFORM) study: methodology, demographics, and baseline clinical characteristics

WK Karlsson, H Ashina, CK Cullum… - The Journal of …, 2023 - Springer
Background Erenumab has demonstrated effectiveness for prevention of migraine attacks,
but the treatment is costly, and a considerable proportion of patients do not respond to it. The …

Methodological considerations on real-world evidence studies of monoclonal antibodies against the CGRP-pathway for migraine: a systematic review

N Vandenbussche, K Pisarek, K Paemeleire - The Journal of Headache …, 2023 - Springer
Background Real-world data are accumulating on the effectiveness, tolerability and safety of
anti-calcitonin gene-related peptide pathway monoclonal antibodies for the preventive …

Two-year effectiveness of erenumab in resistant chronic migraine: a prospective real-world analysis

AP Andreou, M Fuccaro, B Hill, M Murphy… - The Journal of …, 2022 - Springer
Background Controlled and real-world evidence have demonstrated the efficacy of
calcitonin gene related peptide (CGRP) monoclonal antibodies (MABs) in migraine …