Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs

G Zaccara, E Perucca - Epileptic Disorders, 2014 - Wiley Online Library
Interactions between antiepileptic drugs, or between antiepileptic drugs and other drugs,
can be pharmacokinetic or pharmacodynamic in nature. Pharmacokinetic interactions …

Antiepileptic drug interactions-principles and clinical implications

S I. Johannessen… - Current …, 2010 - benthamdirect.com
Antiepileptic drugs (AEDs) are widely used as long-term adjunctive therapy or as
monotherapy in epilepsy and other indications and consist of a group of drugs that are …

Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE …

PN Patsalos, DJ Berry, BFD Bourgeois, JC Cloyd… - …, 2008 - Wiley Online Library
Although no randomized studies have demonstrated a positive impact of therapeutic drug
monitoring (TDM) on clinical outcome in epilepsy, evidence from nonrandomized studies …

Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and …

JO Miners, TM Polasek, JA Hulin, A Rowland… - Pharmacology & …, 2023 - Elsevier
Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …

A mechanistic approach to antiepileptic drug interactions

GD Anderson - Annals of Pharmacotherapy, 1998 - journals.sagepub.com
OBJECTIVE: To describe the primary types of antiepileptic drug (AED) interactions by using
a mechanistic approach. DATA SOURCES: A literature search was performed using …

Drug-drug interactions between psychotropic medications and oral contraceptives

G Schoretsanitis, KM Deligiannidis… - Expert opinion on …, 2022 - Taylor & Francis
Introduction This is a comprehensive overview of pharmacokinetic drug-drug interactions
(DDIs) involving oral contraceptives (OCs) and psychotropic medications. Areas covered …

Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives

DS Reddy - Expert review of clinical pharmacology, 2010 - Taylor & Francis
Contraceptive management in women with epilepsy is critical owing to the potential
maternal and fetal risks if contraception or seizure management fails. This article briefly …

[HTML][HTML] Interactions between hormonal contraception and antiepileptic drugs: clinical and mechanistic considerations

A Reimers, E Brodtkorb, A Sabers - Seizure, 2015 - Elsevier
Antiepileptic drugs (AEDs) and hormonal contraceptives may affect each other's metabolism
and clinical efficacy. Loss of seizure control and unplanned pregnancy may occur when …

Host factors affecting antiepileptic drug delivery—pharmacokinetic variability

CJ Landmark, SI Johannessen, T Tomson - Advanced drug delivery …, 2012 - Elsevier
Antiepileptic drugs (AEDs) are the mainstay in the treatment of epilepsy, one of the most
common serious chronic neurological disorders. AEDs display extensive pharmacological …

The use of hormonal contraception among women taking anticonvulsant therapy

ME Gaffield, KR Culwell, CR Lee - Contraception, 2011 - Elsevier
BACKGROUND: Drug interactions between hormonal contraceptives and anticonvulsants,
resulting in reduced contraceptive effectiveness and/or increased seizure activity, have been …