The n→π* Interaction
Conspectus The carbonyl group holds a prominent position in chemistry and biology not
only because it allows diverse transformations but also because it supports key …
only because it allows diverse transformations but also because it supports key …
Thirty Years of (TMS)3SiH: A Milestone in Radical-Based Synthetic Chemistry
This review is an update on tris (trimethylsilyl) silane, TTMSS, in organic chemistry, focusing
on the advancements of the past decade. The overview includes a wide range of chemical …
on the advancements of the past decade. The overview includes a wide range of chemical …
Fluorinated rings: conformation and application
The introduction of fluorine atoms into molecules and materials across many fields of
academic and industrial research is now commonplace, owing to their unique properties. A …
academic and industrial research is now commonplace, owing to their unique properties. A …
Recent Applications of the (TMS)3SiH Radical-Based Reagent
C Chatgilialoglu, J Lalevée - Molecules, 2012 - mdpi.com
This review article focuses on the recent applications of tris (trimethylsilyl) silane as a radical-
based reagent in organic chemistry. Numerous examples of the successful use of (TMS) …
based reagent in organic chemistry. Numerous examples of the successful use of (TMS) …
Photochemical in-flow synthesis of 2, 4-methanopyrrolidines: pyrrolidine analogues with improved water solubility and reduced lipophilicity
A practical synthesis of 2, 4-methanopyrrolidines was elaborated. The key synthetic step
was an intramolecular photochemical [2+ 2]-cycloaddition of an acrylic acid derivative in …
was an intramolecular photochemical [2+ 2]-cycloaddition of an acrylic acid derivative in …
Fluorine-containing prolines: Synthetic strategies, applications, and opportunities
PK Mykhailiuk - The Journal of Organic Chemistry, 2022 - ACS Publications
Fluorinated prolines play an important role in peptide studies, protein engineering,
medicinal chemistry, drug discovery, and agrochemistry. Since the first synthesis of 4 …
medicinal chemistry, drug discovery, and agrochemistry. Since the first synthesis of 4 …
Peptidyl-prolyl model study: how does the electronic effect influence the amide bond conformation?
The triple-helical structure of collagen, the most abundant protein in animal bodies, owes its
stability to post-translationally installed hydroxyl groups at position 4 of prolyl residues. To …
stability to post-translationally installed hydroxyl groups at position 4 of prolyl residues. To …
α‐CF3‐Substituted Saturated Bicyclic Amines: Advanced Building Blocks for Medicinal Chemistry
O Smyrnov, KP Melnykov, V Semeno… - European Journal of …, 2024 - Wiley Online Library
A straightforward approach to α‐CF3‐substituted saturated bicyclic amines starting from
commercially available compounds is proposed. The key steps include addition of the …
commercially available compounds is proposed. The key steps include addition of the …
Synthesis and physicochemical properties of 3‐fluorocyclobutylamines
AV Chernykh, DS Radchenko… - European Journal of …, 2015 - Wiley Online Library
Hitherto unknown cis‐and trans‐3‐alkyl‐and 3‐aryl‐3‐fluorocycobutylamines have been
synthesised selectively from 3‐oxocyclobutane carboxylic acid in six or seven steps …
synthesised selectively from 3‐oxocyclobutane carboxylic acid in six or seven steps …
A Proline Mimetic for the Design of New Stable Secondary Structures: Solvent-Dependent Amide Bond Isomerization of (S)-Indoline-2-carboxylic Acid Derivatives
A thorough experimental and computational study on the conformational properties of (S)-
indoline-2-carboxylic acid derivatives has been conducted. Methyl (S)-1-acetylindoline-2 …
indoline-2-carboxylic acid derivatives has been conducted. Methyl (S)-1-acetylindoline-2 …