Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges
Immunotherapy has emerged as a major therapeutic modality in oncology. Currently,
however, the majority of patients with cancer do not derive benefit from these treatments …
however, the majority of patients with cancer do not derive benefit from these treatments …
Signaling pathways and intervention therapies in sepsis
Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …
systemic inflammatory and immune response to infection. Over decades, advanced …
Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy
Lymphodepletion chemotherapy followed by infusion of CD19-specific chimeric antigen
receptor–modified (CAR) T cells has produced impressive antitumor responses in patients …
receptor–modified (CAR) T cells has produced impressive antitumor responses in patients …
Role of angiopoietin-2 in vascular physiology and pathophysiology
Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19
RS Thwaites, A Sanchez Sevilla Uruchurtu… - Science …, 2021 - science.org
While it is now widely accepted that host inflammatory responses contribute to lung injury,
the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from …
the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from …
Endothelial/pericyte interactions
Interactions between endothelial cells and mural cells (pericytes and vascular smooth
muscle cells) in the blood vessel wall have recently come into focus as central processes in …
muscle cells) in the blood vessel wall have recently come into focus as central processes in …
Mechanisms of cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies
X **ao, S Huang, S Chen, Y Wang, Q Sun… - Journal of Experimental & …, 2021 - Springer
Chimeric antigen receptor (CAR) T-cell therapy has yielded impressive outcomes and
transformed treatment algorithms for hematological malignancies. To date, five CAR T-cell …
transformed treatment algorithms for hematological malignancies. To date, five CAR T-cell …
Hypoxia signalling in cancer and approaches to enforce tumour regression
Tumour cells emerge as a result of genetic alteration of signal circuitries promoting cell
growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is …
growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is …
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls
embryonic development and is also involved in numerous life-threatening human diseases …
embryonic development and is also involved in numerous life-threatening human diseases …
Therapeutic targeting of the angiopoietin–TIE pathway
P Saharinen, L Eklund, K Alitalo - Nature Reviews Drug Discovery, 2017 - nature.com
The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …
permeability and pathological vascular remodelling during inflammation, tumour …