Envelope structures of Gram-positive bacteria

M Rajagopal, S Walker - Protein and sugar export and assembly in Gram …, 2017‏ - Springer
Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus
pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate …

Lipoteichoic acid synthesis and function in gram-positive bacteria

MG Percy, A Gründling - Annual review of microbiology, 2014‏ - annualreviews.org
Lipoteichoic acid (LTA) is an important cell wall polymer found in gram-positive bacteria.
Although the exact role of LTA is unknown, mutants display significant growth and …

[HTML][HTML] Structural and functional aspects of the nonribosomal peptide synthetase condensation domain superfamily: discovery, dissection and diversity

K Bloudoff, TM Schmeing - Biochimica et Biophysica Acta (BBA)-Proteins …, 2017‏ - Elsevier
Nonribosomal peptide synthetases (NRPSs) are incredible macromolecular machines that
produce a wide range of biologically-and therapeutically-relevant molecules. During …

Nonribosomal peptide synthetases: structures and dynamics

M Strieker, A Tanović, MA Marahiel - Current opinion in structural biology, 2010‏ - Elsevier
Nonribosomal peptide synthetases (NRPSs) are large multimodular biocatalysts that utilize
complex regiospecific and stereospecific reactions to assemble structurally and functionally …

Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase

AM Gulick - ACS chemical biology, 2009‏ - ACS Publications
The ANL superfamily of adenylating enzymes contains acyl-and aryl-CoA synthetases, firefly
luciferase, and the adenylation domains of the modular non-ribosomal peptide synthetases …

Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology

GH Hur, CR Vickery, MD Burkart - Natural product reports, 2012‏ - pubs.rsc.org
Covering up to the end of 2011 Many pharmaceuticals on the market today belong to a large
class of natural products called nonribosomal peptides (NRPs). Originating from bacteria …

Enzymatic synthesis of azide by a promiscuous N-nitrosylase

A Del Rio Flores, R Zhai, DW Kastner, K Seshadri… - Nature Chemistry, 2024‏ - nature.com
Azides are energy-rich compounds with diverse representation in a broad range of scientific
disciplines, including material science, synthetic chemistry, pharmaceutical science and …

Structural biology of nonribosomal peptide synthetases

BR Miller, AM Gulick - … Peptide and Polyketide Biosynthesis: Methods and …, 2016‏ - Springer
The nonribosomal peptide synthetases are modular enzymes that catalyze synthesis of
important peptide products from a variety of standard and non-proteinogenic amino acid …

Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule

C Qin, LG Graf, K Striska, M Janetzky, N Geist… - Nature …, 2024‏ - nature.com
The AMP-forming acetyl-CoA synthetase is regulated by lysine acetylation both in bacteria
and eukaryotes. However, the underlying mechanism is poorly understood. The Bacillus …

Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases

KD Patel, MR MacDonald, SF Ahmed, J Singh… - Natural Product …, 2023‏ - pubs.rsc.org
Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …