[HTML][HTML] Are cell jamming and unjamming essential in tissue development?
The last decade has seen a surge of evidence supporting the existence of the transition of
the multicellular tissue from a collective material phase that is regarded as being jammed to …
the multicellular tissue from a collective material phase that is regarded as being jammed to …
Multiple aspects of matrix stiffness in cancer progression
A Mancini, MT Gentile, F Pentimalli… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial
in the processes of cell differentiation and proliferation. However, it is unclear to what extent …
in the processes of cell differentiation and proliferation. However, it is unclear to what extent …
Shear-driven solidification and nonlinear elasticity in epithelial tissues
Biological processes, from morphogenesis to tumor invasion, spontaneously generate shear
stresses inside living tissue. The mechanisms that govern the transmission of mechanical …
stresses inside living tissue. The mechanisms that govern the transmission of mechanical …
A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation
It is well established that the early malignant tumor invades surrounding extracellular matrix
(ECM) in a manner that depends upon material properties of constituent cells, surrounding …
(ECM) in a manner that depends upon material properties of constituent cells, surrounding …
Pulling the strings on solid-to-liquid phase transitions in cell collectives
Cell collectives must dynamically adapt to different biological contexts. For instance, in
homeostatic conditions, epithelia must establish a barrier between body compartments and …
homeostatic conditions, epithelia must establish a barrier between body compartments and …
Epithelial layer unjamming shifts energy metabolism toward glycolysis
In development of an embryo, healing of a wound, or progression of a carcinoma, a requisite
event is collective epithelial cellular migration. For example, cells at the advancing front of a …
event is collective epithelial cellular migration. For example, cells at the advancing front of a …
Mechanical compression of human airway epithelial cells induces release of extracellular vesicles containing tenascin C
Aberrant remodeling of the asthmatic airway is not well understood but is thought to be
attributable in part to mechanical compression of airway epithelial cells. Here, we examine …
attributable in part to mechanical compression of airway epithelial cells. Here, we examine …
[HTML][HTML] Integrating mechanical cues with engineered platforms to explore cardiopulmonary development and disease
Mechanical forces provide critical biological signals to cells during healthy and aberrant
organ development as well as during disease processes in adults. Within the …
organ development as well as during disease processes in adults. Within the …
On the origins of order
JJ Fredberg - Soft Matter, 2022 - pubs.rsc.org
A cardinal feature common to embryonic development and tissue reorganization, as well as
to wound healing and cancer cell invasion, is collective cellular migration. During collective …
to wound healing and cancer cell invasion, is collective cellular migration. During collective …
Jamming transitions in astrocytes and glioblastoma are induced by cell density and tension
U Hohmann, JC von Widdern, C Ghadban… - Cells, 2022 - mdpi.com
Collective behavior of cells emerges from coordination of cell–cell-interactions and is
important to wound healing, embryonic and tumor development. Depending on cell density …
important to wound healing, embryonic and tumor development. Depending on cell density …