Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …

Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

Personalized medicine is expected to benefit from combining genomic information with
regular monitoring of physiological states by multiple high-throughput methods. Here, we …

Alternative splicing (AS) enables programmed diversity of gene expression across tissues
and development. We show here that binding in distal intronic regions (> 500 nucleotides …

Epithelial cancers make up the vast majority of cancer types and, during the transition from
benign adenoma to malignant carcinoma and metastasis, epithelial tumor cells acquire a de …

Understanding how RNA binding proteins control the splicing code is fundamental to human
biology and disease. Here, we present a comprehensive study to elucidate how …

Epithelial-mesenchymal transition (EMT), a mechanism important for embryonic
development, plays a critical role during malignant transformation. While much is known …

The relationship between drug resistance, changes in signaling, and emergence of an
invasive phenotype is well appreciated, but the underlying mechanisms are not well …

Background First-generation molecular profiles for human breast cancers have enabled the
identification of features that can predict therapeutic response; however, little is known about …