The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer
JR Inigo, D Chandra - Journal of hematology & oncology, 2022 - Springer
Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …
Growth inhibitory signaling of the Raf/MEK/ERK pathway
PK Wu, A Becker, JI Park - International journal of molecular sciences, 2020 - mdpi.com
In response to extracellular stimuli, the Raf/MEK/extracellular signal-regulated kinase (ERK)
pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling …
pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling …
Why is mortalin a potential therapeutic target for cancer?
Cancer is one of the leading causes of death worldwide, accounting for nearly 10 million
deaths in 2020. Therefore, cancer therapy is a priority research field to explore the biology of …
deaths in 2020. Therefore, cancer therapy is a priority research field to explore the biology of …
Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels
While cellular LC3B and SQSTM1 levels serve as key autophagy markers, their regulation
by different signaling pathways requires better understanding. Here, we report the …
by different signaling pathways requires better understanding. Here, we report the …
Mortalin: Protein partners, biological impacts, pathological roles, and therapeutic opportunities
N Esfahanian, CD Knoblich, GA Bowman… - Frontiers in Cell and …, 2023 - frontiersin.org
Mortalin (GRP75, HSPA9A), a heat shock protein (HSP), regulates a wide range of cellular
processes, including cell survival, growth, and metabolism. The regulatory functions of …
processes, including cell survival, growth, and metabolism. The regulatory functions of …
A bird's eye view of mitochondrial unfolded protein response in cancer: mechanisms, progression and further applications
X Zhang, Y Fan, K Tan - Cell Death & Disease, 2024 - nature.com
Mitochondria are essential organelles that play critical roles in energy metabolism,
apoptosis and various cellular processes. Accumulating evidence suggests that …
apoptosis and various cellular processes. Accumulating evidence suggests that …
LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway
Y **ng, Y Liu, Z Qi, Z Liu, X Wang, H Zhang - Cellular & Molecular Biology …, 2021 - Springer
Background Hepatocellular carcinoma (HCC) is now the second leading cause of cancer
death worldwide and lacks effectual therapy due to its high rate of tumor recurrence and …
death worldwide and lacks effectual therapy due to its high rate of tumor recurrence and …
Mortalin (GRP75/HSPA9) promotes survival and proliferation of thyroid carcinoma cells
We previously reported that upregulation of mortalin (HSPA9/GRP75), the mitochondrial
HSP70 chaperone, facilitates tumor cell proliferation and survival in human medullary …
HSP70 chaperone, facilitates tumor cell proliferation and survival in human medullary …
Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations
in the rearranged during transfection (RET) proto-oncogene. For therapy of advanced MTC …
in the rearranged during transfection (RET) proto-oncogene. For therapy of advanced MTC …
Restoration of p53 functions by suppression of mortalin–p53 sequestration: an emerging target in cancer therapy
Functional inactivation of wild-type p53 is a major trait of cancerous cells. In many cases,
such inactivation occurs by either TP53 gene mutations or due to overexpression of p53 …
such inactivation occurs by either TP53 gene mutations or due to overexpression of p53 …