Mutant p53 in cancer: from molecular mechanism to therapeutic modulation
X Chen, T Zhang, W Su, Z Dou, D Zhao, X **… - Cell Death & …, 2022 - nature.com
TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …
The multiple mechanisms that regulate p53 activity and cell fate
A Hafner, ML Bulyk, A Jambhekar… - Nature reviews Molecular …, 2019 - nature.com
The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
Targeting a neoantigen derived from a common TP53 mutation
INTRODUCTION TP53 (tumor protein P53), a tumor suppressor gene, is the most commonly
mutated cancer-driver gene. Nevertheless, drugs that target mutant p53, the protein product …
mutated cancer-driver gene. Nevertheless, drugs that target mutant p53, the protein product …
Integrated analysis of TP53 gene and pathway alterations in the cancer genome atlas
The TP53 tumor suppressor gene is frequently mutated in human cancers. An analysis of
five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer …
five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer …
Metformin and its benefits for various diseases
Z Lv, Y Guo - Frontiers in endocrinology, 2020 - frontiersin.org
Metformin is a widely used biguanide drug due to its safety and low cost. It has been used
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …
Nucleic acid tests for clinical translation
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
The tumour suppressor gene TP53 is mutated in~ 50% of human cancers. In addition to its
function in tumour suppression, p53 also plays a major role in the response of malignant as …
function in tumour suppression, p53 also plays a major role in the response of malignant as …
The significance of mitochondrial dysfunction in cancer
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …
energy metabolism, maintenance of redox balance, and regulation of apoptosis …
The p53 network: cellular and systemic DNA damage responses in cancer and aging
The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most
frequently mutated gene in human cancers. p53 plays a central role in responding to DNA …
frequently mutated gene in human cancers. p53 plays a central role in responding to DNA …
Mutant p53 in cancer progression and targeted therapies
G Zhu, C Pan, JX Bei, B Li, C Liang, Y Xu, X Fu - Frontiers in oncology, 2020 - frontiersin.org
TP53 is the most frequently mutated tumor suppressor gene in human cancer. The majority
of mutations of p53 are missense mutations, leading to the expression of the full length p53 …
of mutations of p53 are missense mutations, leading to the expression of the full length p53 …