Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Abstract Structure and function are highly correlated in the vertebrate retina, a sensory tissue
that is organized into cell layers with microcircuits working in parallel and together to encode …

In this report, we demonstrate that an optic cup structure can form by self-organization in
human ESC culture. The human ESC-derived optic cup is much larger than the mouse ESC …

Müller glia are the major glial component of the retina. They are one of the last retinal cell
types to be born during development, and they function to maintain retinal homeostasis and …

Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …

INTRODUCTION Cone photoreceptors in the human retina enable daytime, color, and high-
acuity vision. The three subtypes of human cones are defined by the visual pigment that they …

Photoreceptor replacement by transplantation is proposed as a treatment for blindness.
Transplantation of healthy photoreceptor precursor cells into diseased murine eyes leads to …

Retinal transplantation therapy for retinitis pigmentosa is increasingly of interest due to
accumulating evidence of transplantation efficacy from animal studies and development of …

Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent
stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited …

Inherited retinal degenerations (IRDs) represent a diverse group of progressive, visually
debilitating diseases that can lead to blindness in which mutations in genes that are critical …