Precision medicine in human heart modeling: perspectives, challenges, and opportunities
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
Three-dimensional cardiac computational modelling: methods, features and applications
The combination of computational models and biophysical simulations can help to interpret
an array of experimental data and contribute to the understanding, diagnosis and treatment …
an array of experimental data and contribute to the understanding, diagnosis and treatment …
Generating Purkinje networks in the human heart
The Purkinje network is an integral part of the excitation system in the human heart. Yet, to
date, there is no in vivo imaging technique to accurately reconstruct its geometry and …
date, there is no in vivo imaging technique to accurately reconstruct its geometry and …
Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks
Cardiac Purkinje networks are a fundamental part of the conduction system and are known
to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje …
to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje …
[HTML][HTML] Inference of ventricular activation properties from non-invasive electrocardiography
The realisation of precision cardiology requires novel techniques for the non-invasive
characterisation of individual patients' cardiac function to inform therapeutic and diagnostic …
characterisation of individual patients' cardiac function to inform therapeutic and diagnostic …
Modeling our understanding of the His-Purkinje system
EJ Vigmond, BD Stuyvers - Progress in biophysics and molecular biology, 2016 - Elsevier
Abstract The His-Purkinje System (HPS) is responsible for the rapid electric conduction in
the ventricles. It relays electrical impulses from the atrioventricular node to the muscle cells …
the ventricles. It relays electrical impulses from the atrioventricular node to the muscle cells …
Estimation of personalized minimal purkinje systems from human electro-anatomical maps
The Purkinje system is a heart structure responsible for transmitting electrical impulses
through the ventricles in a fast and coordinated way to trigger mechanical contraction …
through the ventricles in a fast and coordinated way to trigger mechanical contraction …
The role of Purkinje-myocardial coupling during ventricular arrhythmia: a modeling study
E Behradfar, A Nygren, EJ Vigmond - PloS one, 2014 - journals.plos.org
The Purkinje system is the fast conduction network of the heart which couples to the
myocardium at discrete sites called Purkinje-Myocyte Junctions (PMJs). However, the …
myocardium at discrete sites called Purkinje-Myocyte Junctions (PMJs). However, the …
Probabilistic learning of the Purkinje network from the electrocardiogram
The identification of the Purkinje conduction system in the heart is a challenging task, yet
essential for a correct definition of cardiac digital twins for precision cardiology. Here, we …
essential for a correct definition of cardiac digital twins for precision cardiology. Here, we …
3D bioprinting the cardiac Purkinje system using human adipogenic mesenchymal stem cell derived Purkinje cells
EP Tracy, BC Gettler, JS Zakhari, RJ Schwartz… - Cardiovascular …, 2020 - Springer
Purpose The objective of this study was to reprogram human adipogenic mesenchymal stem
cells (hADMSCs) to form Purkinje cells and to use the reprogrammed Purkinje cells to …
cells (hADMSCs) to form Purkinje cells and to use the reprogrammed Purkinje cells to …