Cerebral cavernous malformation: from mechanism to therapy

DA Snellings, CC Hong, AA Ren… - Circulation …, 2021 - Am Heart Assoc
Cerebral cavernous malformations are acquired vascular anomalies that constitute a
common cause of central nervous system hemorrhage and stroke. The past 2 decades have …

Cerebral intraparenchymal hemorrhage: a review

BA Gross, BT Jankowitz, RM Friedlander - Jama, 2019 - jamanetwork.com
Importance Although spontaneous intraparenchymal hemorrhage (IPH) accounts for less
than 20% of cases of stroke, it continues to be associated with the highest mortality of all …

Cerebral cavernous malformation: what a practicing clinician should know

KD Flemming, G Lanzino - Mayo Clinic Proceedings, 2020 - Elsevier
Cavernous malformations (CMs) are angiographically occult, low-flow vascular
malformations of the central nervous system. They are acquired lesions, with approximately …

Cranial cavernous malformations: natural history and treatment

CJ Stapleton, FG Barker - Stroke, 2018 - Am Heart Assoc
2 Stroke April 2018 (20.8%), and focal neurological deficit (15.2%). Of the 1620 CMs
analyzed, 50% were located in the cerebral hemispheres, 35% in the brain stem, 8% in the …

Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice

MA Lopez-Ramirez, A Pham, R Girard… - Blood, The Journal …, 2019 - ashpublications.org
Cerebral cavernous malformations (CCMs) are common brain vascular dysplasias that are
prone to acute and chronic hemorrhage with significant clinical sequelae. The pathogenesis …

Cerebral cavernous malformations: an update on prevalence, molecular genetic analyses, and genetic counselling

S Spiegler, M Rath, C Paperlein, U Felbor - Molecular syndromology, 2018 - karger.com
Based on the latest gnomAD dataset, the prevalence of symptomatic hereditary cerebral
cavernous malformations (CCMs) prone to cause epileptic seizures and stroke-like …

Propranolol for familial cerebral cavernous malformation (Treat_CCM): study protocol for a randomized controlled pilot trial

S Lanfranconi, E Scola, GA Bertani, B Zarino, R Pallini… - Trials, 2020 - Springer
Abstract Background Cerebral cavernous malformations (CCMs) are vascular malformations
characterized by clusters of enlarged leaky capillaries in the central nervous system. They …

[HTML][HTML] Natural history of brainstem cavernous malformations: prospective hemorrhage rate and adverse factors in a consecutive prospective cohort

D Li, ZY Wu, PP Liu, JP Ma, XL Huo, L Wang… - Journal of …, 2020 - thejns.org
OBJECTIVE Given the paucity of data on the natural history of brainstem cavernous
malformations (CMs), the authors aimed to evaluate the annual hemorrhage rate and …

Hemorrhage from cerebral cavernous malformations: the role of associated developmental venous anomalies

B Chen, A Herten, D Saban, S Rauscher, A Radbruch… - Neurology, 2020 - AAN Enterprises
Objective To determine the role of associated developmental venous anomalies (DVAs) in
intracranial hemorrhage (ICH) caused by cerebral cavernous malformations (CCMs) …

[HTML][HTML] Cerebral cavernous malformation, familial

L Morrison, A Akers - 2016 - europepmc.org
Cerebral cavernous malformations (CCMs) are vascular malformations in the brain and
spinal cord comprising closely clustered, enlarged capillary channels (caverns) with a single …