Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer
Novel effective treatment is direly needed for patients with pancreatic ductal
adenocarcinoma (PDAC). Therapeutics that target the driver mutations, especially the KRAS …
adenocarcinoma (PDAC). Therapeutics that target the driver mutations, especially the KRAS …
Lipid metabolism associated crosstalk: the bidirectional interaction between cancer cells and immune/stromal cells within the tumor microenvironment for prognostic …
Z Lin, G Hua, X Hu - Cancer Cell International, 2024 - Springer
Cancer is closely related to lipid metabolism, with the tumor microenvironment (TME)
containing numerous lipid metabolic interactions. Cancer cells can bidirectionally interact …
containing numerous lipid metabolic interactions. Cancer cells can bidirectionally interact …
[HTML][HTML] Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway
W Cao, Z Zeng, Z He, S Lei - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Pancreatic stellate cells (PSCs) are important components of the tumor microenvironment in
pancreatic cancer (PC) and contribute to its development and metastasis through …
pancreatic cancer (PC) and contribute to its development and metastasis through …
A novel pancreatic tumour and stellate cell 3D co-culture spheroid model
KJ Norberg, X Liu, C Fernández Moro, C Strell, S Nania… - BMC cancer, 2020 - Springer
Background Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome,
generally characterized by an excessive stroma component. The purpose of this study was …
generally characterized by an excessive stroma component. The purpose of this study was …
Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species
Pancreatic cancer is a highly challenging malignancy with extremely poor prognosis.
Cytoglobin (CYGB), a hemeprotein involved in liver fibrosis and cancer development, is …
Cytoglobin (CYGB), a hemeprotein involved in liver fibrosis and cancer development, is …
Pancreatic cancer tumor microenvironment is a major therapeutic barrier and target
C Hartupee, BM Nagalo, CY Chabu, MZ Tesfay… - Frontiers in …, 2024 - frontiersin.org
Pancreatic Ductal Adenocarcinoma (PDAC) is projected to become the 2nd leading cause of
cancer-related deaths in the United States. Limitations in early detection and treatment …
cancer-related deaths in the United States. Limitations in early detection and treatment …
Mechanically stressed cancer microenvironment: Role in pancreatic cancer progression
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies in
the world due to its insensitivity to current therapies and its propensity to metastases from the …
the world due to its insensitivity to current therapies and its propensity to metastases from the …
TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation
Pancreatic stellate cell (PSC) activation is a major event occurring during pancreatic ductal
adenocarcinoma (PDAC) development. Up to now mechanisms underlying their activation …
adenocarcinoma (PDAC) development. Up to now mechanisms underlying their activation …
Stellate cells aid growth-permissive metabolic reprogramming and promote gemcitabine chemoresistance in pancreatic cancer
M Amrutkar, IP Gladhaug - Cancers, 2021 - mdpi.com
Simple Summary The great majority, more than 90%, of patients with pancreatic ductal
adenocarcinoma (PDAC) die within less than five years after detection of the disease …
adenocarcinoma (PDAC) die within less than five years after detection of the disease …
Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapy
Z Wang, R He, S Dong, W Zhou - Frontiers in oncology, 2023 - frontiersin.org
Pancreatic cancer is a strongly malignant gastrointestinal carcinoma characterized by late
detection, high mortality rates, poor patient prognosis and lack of effective treatments …
detection, high mortality rates, poor patient prognosis and lack of effective treatments …