Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era

S Castañeda-Barba, EM Top, T Stalder - Nature Reviews Microbiology, 2024 - nature.com
Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …

Prevalence and hazardous impact of pharmaceutical and personal care products and antibiotics in environment: A review on emerging contaminants

P Chaturvedi, P Shukla, BS Giri, P Chowdhary… - Environmental …, 2021 - Elsevier
Antibiotic resistance is a global health emergency linked to unrestrained use of
pharmaceutical and personal care products (PPCPs) as prophylactic agent and therapeutic …

Programmable synthetic biomolecular condensates for cellular control

Y Dai, M Farag, D Lee, X Zeng, K Kim, H Son… - Nature Chemical …, 2023 - nature.com
The formation of biomolecular condensates mediated by a coupling of associative and
segregative phase transitions plays a critical role in controlling diverse cellular functions in …

Beyond horizontal gene transfer: the role of plasmids in bacterial evolution

J Rodríguez-Beltrán, J DelaFuente… - Nature Reviews …, 2021 - nature.com
Plasmids have a key role in bacterial ecology and evolution because they mobilize
accessory genes by horizontal gene transfer. However, recent studies have revealed that …

[HTML][HTML] Elevated rates of horizontal gene transfer in the industrialized human microbiome

M Groussin, M Poyet, A Sistiaga, SM Kearney, K Moniz… - Cell, 2021 - cell.com
Industrialization has impacted the human gut ecosystem, resulting in altered microbiome
composition and diversity. Whether bacterial genomes may also adapt to the …

[HTML][HTML] Antibiotic-resistant bacteria in aquaculture and climate change: A challenge for health in the Mediterranean area

M Pepi, S Focardi - International journal of environmental research and …, 2021 - mdpi.com
Aquaculture is the productive activity that will play a crucial role in the challenges of the
millennium, such as the need for proteins that support humans and the respect for the …

Clinically relevant mutations in core metabolic genes confer antibiotic resistance

AJ Lopatkin, SC Bening, AL Manson, JM Stokes… - Science, 2021 - science.org
Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is
generally associated with drug target modification, enzymatic inactivation, and/or transport …

Two defence systems eliminate plasmids from seventh pandemic Vibrio cholerae

M Jaskólska, DW Adams, M Blokesch - Nature, 2022 - nature.com
Horizontal gene transfer can trigger rapid shifts in bacterial evolution. Driven by a variety of
mobile genetic elements—in particular bacteriophages and plasmids—the ability to share …

Antibiotic resistance genes from livestock waste: occurrence, dissemination, and treatment

Y He, Q Yuan, J Mathieu, L Stadler, N Senehi, R Sun… - NPJ Clean …, 2020 - nature.com
Antibiotics are widely used in animal husbandry, and various types of antibiotic resistance
genes (ARGs) are frequently detected in livestock waste around the world. Conventional …

Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …