The importance of the kynurenine pathway in normal immune system function has led to an
appreciation of its possible contribution to autoimmune disorders such as rheumatoid …

Simple Summary There is clear evidence that inflammation can contribute to the
development of cancers, but the underlying mechanisms are not fully understood. This …

Although the central nervous system (CNS) and immune system were regarded as
independent entities, it is now clear that immune system cells can influence the CNS, and …

Although ionotropic glutamate receptors and nicotinic receptors for acetylcholine (ACh) have
usually been studied separately, they are often co-localized and functionally inter …

It has been unequivocally established that kynurenic acid has a number of actions in a
variety of cells and tissues, raising, in principle, the possibility of targeting its generation …

Two of the molecular families closely associated with mediating communication between the
brain and immune system are cytokines and the kynurenine metabolites of tryptophan. Both …

Abstract The Kynurenine aminotransferase II (KATII) enzyme has an essential role in L-
kynurenine transmission to kynurenic acid (KYNA). High concentration of kynurenic acid …

Several lines of evidence support the hypothesis that abnormally elevated brain levels of
kynurenic acid (KYNA), a metabolite of the kynurenine pathway (KP) of tryptophan …

Neuroinflammation is one of the most frequently studied topics of neurosciences as it is a
common feature in almost all neurological disorders. Although the primary function of …

Kynurenic acid is a neuroprotective metabolite of tryptophan formed by kynurenine
aminotransferase (KAT) catalyzed transformation of kynurenine. However, its high brain …