The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

Role of IKr in Rabbit Sinoatrial Node. Introduction: A rapidly activating delayed rectifier
potassium current (IKr) is known to have an important role in determining the properties of …

We have shown that 5 days of mild hypoxia has significant effects on fetal ECoG activity,
heart rate and blood pressure. We now studied if mild prolonged hypoxemia had an adverse …

To investigate the basis of ischemia-induced bradycardia (< 60 beats/min), we isolated
pacemaker cells from the rabbit sinoatrial node and exposed them to ischemic-like …

Recent evidence from intact hearts suggests that the function of cardiac nodal tissue may be
particularly susceptible to acidosis. Little is currently known, however, about the effects of …

The sinoatrial node (SAN), the pacemaker of the mammalian heart, possesses intrinsic
automaticity. Dysfunction of the SAN may lead to abnormal cardiac rhythms, manifested by …

IMPLICATIONS: In this animal study pretreatment with bupivacaine attenuated the
progression of myocardial acidosis during ventricular fibrillation. The dogs regained normal …

The early effects of metabolic inhibition on intracellular Ca2+ concentration ([Ca2+] i), Ca2+
current, and sarcoplasmic reticulum (SR) Ca2+ content were studied in single pacemaker …

Ischemic-like conditions (a glucose-free, pH 6.6 Tyrode solution bubbled with 100% N2)
enhance L-type Ca current (I Ca, L) in single pacemaker cells (PCs) isolated from the rabbit …

AIMS: Lactic acidosis causes atrial fibrillation (AF), and pulmonary veins (PVs) are the most
important focus for the generation of AF. Cariporide (HOE642), a Na+/H+ blocker, can …