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Ankylosing spondylitis: etiology, pathogenesis, and treatments
Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …
Present yourself! By MHC class I and MHC class II molecules
Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture
of how MHC class I and MHC class II molecules really work. This is a story of the proteases …
of how MHC class I and MHC class II molecules really work. This is a story of the proteases …
Pathways of antigen processing
T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …
Towards a systems understanding of MHC class I and MHC class II antigen presentation
The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …
molecules have been studied extensively for almost three decades. Although the basic …
[HTML][HTML] Role of HLA-B27 in the pathogenesis of ankylosing spondylitis
B Chen, J Li, C He, D Li, W Tong… - Molecular medicine …, 2017 - spandidos-publications.com
The study of ankylosing spondylitis (AS) has made significant progress over the last decade.
Genome-wide association studies have identified and further substantiated the role of …
Genome-wide association studies have identified and further substantiated the role of …
Antigen processing and presentation in cancer immunotherapy
Background Knowledge about and identification of T cell tumor antigens may inform the
development of T cell receptor-engineered adoptive cell transfer or personalized cancer …
development of T cell receptor-engineered adoptive cell transfer or personalized cancer …
How ERAP1 and ERAP2 shape the peptidomes of disease-associated MHC-I proteins
JA López de Castro - Frontiers in immunology, 2018 - frontiersin.org
Four inflammatory diseases are strongly associated with Major Histocompatibility Complex
class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A* 29: 02), ankylosing …
class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A* 29: 02), ankylosing …
A large-scale screen for coding variants predisposing to psoriasis
To explore the contribution of functional coding variants to psoriasis, we analyzed
nonsynonymous single-nucleotide variants (SNVs) across the genome by exome …
nonsynonymous single-nucleotide variants (SNVs) across the genome by exome …
The pathogenesis of ankylosing spondylitis: an update
Abstract Purpose of Review Ankylosing spondyloarthritis (AS) is a chronic inflammatory
disease that involves the axial joints and entheses. Extra-spinal manifestations such as …
disease that involves the axial joints and entheses. Extra-spinal manifestations such as …
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming
Endoplasmatic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in
trimming of peptides to an optimal length for presentation by major histocompatibility …
trimming of peptides to an optimal length for presentation by major histocompatibility …