The Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA) approach has been
widely applied as an efficient and reliable free energy simulation method to model molecular …

Antimicrobial peptides are a type of small-molecule peptide that widely exist in nature and
are components of the innate immunity of almost all living things. They play an important role …

The highly conserved histones in different species seem to represent a very ancient and
universal innate host defense system against microorganisms in the biological world …

Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial
activities against infectious bacteria, viruses, and fungi. Increasing evidence suggests that …

Host‐defense peptides (HDPs) feature evolution‐tested potency against life‐threatening
pathogens. While piscidin 1 (p1) and piscidin 3 (p3) are homologous and potent fish HDPs …

Antibiotics are cytotoxic or cytostatic compounds, very effective, harmful and specific against
pathogenic microorganisms that have saved millions of lives and increased human life …

The large abundance of small open reading frames (smORFs) in prokaryotic and eukaryotic
genomes and the plethora of smORF‐encoded small proteins became only apparent with …

In an era where the pipeline of new antibiotic development is drying up, the continuous rise
of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine …

The significance of the complex bacterial ecosystem in the human body and the impediment
of the mammalian membrane against many antibiotics together emphasize the necessity to …

Fish is an important source of antimicrobial peptides. This study aimed to identify and screen
antibacterial peptides with excellent antibacterial activity derived from sturgeon spermary …