The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

P Lacolley, V Regnault, A Nicoletti, Z Li… - Cardiovascular …, 2012 - academic.oup.com
Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, continually
exposed to mechanical signals and biochemical components generated in the blood …

Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction

JD Upadhyaya, N Singh, AS Sikarwar, R Chakraborty… - PLoS …, 2014 - journals.plos.org
Activation of bitter taste receptors (T2Rs) in human airway smooth muscle cells leads to
muscle relaxation and bronchodilation. This finding led to our hypothesis that T2Rs are …

[HTML][HTML] Carvacrol protects against diabetes-induced hypercontractility in the aorta through activation of the PI3K/Akt pathway

Y Liu, J Wei, KT Ma, CL Li, YP Mai, XX Qiu… - Biomedicine & …, 2020 - Elsevier
Vascular complications induced by diabetes constitute the principal cause of morbidity and
mortality in diabetic patients. It has been reported that carvacrol (CAR) possesses a wide …

Characterization of human vocal fold fibroblasts derived from chronic scar

ME Jetté, SD Hayer, SL Thibeault - The Laryngoscope, 2013 - Wiley Online Library
Abstract Objectives/Hypothesis: In vitro modeling of cell‐matrix interactions that occur during
human vocal fold scarring is uncommon, as primary human vocal fold scar fibroblast cell …

Osteoprotegerin deficiency limits angiotensin II–induced aortic dilatation and rupture in the apolipoprotein E–knockout mouse

CS Moran, RJ Jose, E Biros… - … , thrombosis, and vascular …, 2014 - Am Heart Assoc
Objective—Mounting evidence links osteoprotegerin with cardiovascular disease. Elevated
serum and aortic tissue osteoprotegerin are associated with the presence and growth of …

Emerging role of angiotensin type 2 receptor (AT2R)/Akt/NO pathway in vascular smooth muscle cell in the hyperthyroidism

MA Carrillo-Sepúlveda, GS Ceravolo, CR Furstenau… - PloS one, 2013 - journals.plos.org
Hyperthyroidism is characterized by increased vascular relaxation and decreased vascular
contraction and is associated with augmented levels of triiodothyronine (T3) that contribute …

[HTML][HTML] Phenotypic modulation of mesenteric vascular smooth muscle cells from type 2 diabetic rats is associated with decreased caveolin-1 expression

MA Carrillo-Sepulveda, T Matsumoto - Cellular Physiology and …, 2014 - karger.com
Aims: Diabetes-induced vascular complications are associated with vascular smooth muscle
cell (VSMC) phenotypic modulation, switching from a contractile to a synthetic-proliferative …

miR‐217 alleviates high‐glucose‐induced vascular smooth muscle cell dysfunction via regulating ROCK1

W Zhou, S Ye, W Wang - Journal of Biochemical and Molecular …, 2021 - Wiley Online Library
Abstract MicroRNA‐217 (miR‐217) has been recently reported to be abnormally expressed
during atherosclerosis. Nonetheless, it still remains unknown whether miR‐217 can regulate …

[HTML][HTML] Angiotensin (1-7) inhibits Ang II-mediated ERK1/2 activation by stimulating MKP-1 activation in vascular smooth muscle cells

A Sousa-Lopes, RA de Freitas… - … Journal of Molecular …, 2020 - ncbi.nlm.nih.gov
The renin–angiotensin system (RAS) exerts profound physiological effects on blood
pressure regulation and fluid homeostasis, mainly by modulating renal, cardiovascular, and …

Modulation of Kinin B2 Receptor Signaling Controls Aortic Dilatation and Rupture in the Angiotensin II–Infused Apolipoprotein E–Deficient Mouse

CS Moran, CM Rush, T Dougan, RJ Jose… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Abdominal aortic aneurysm (AAA) is an important cause of mortality in older
adults. Activity of the local kallikrein–kinin system may be important in cardiovascular …