The stringent response and physiological roles of (pp) pGpp in bacteria
SE Irving, NR Choudhury, RM Corrigan - Nature Reviews Microbiology, 2021 - nature.com
The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
Recent functional insights into the role of (p) ppGpp in bacterial physiology
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
Intracellular Staphylococcus aureus persisters upon antibiotic exposure
Bacterial persister cells are phenotypic variants that exhibit a transient non-growing state
and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus …
and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus …
Staphylococcus aureus toxins
M Otto - Current opinion in microbiology, 2014 - Elsevier
Highlights•S. aureus produces a wide variety of toxins mostly aimed to evade elimination by
host defenses.•Many S. aureus toxins are encoded on mobile genetic elements, leading to a …
host defenses.•Many S. aureus toxins are encoded on mobile genetic elements, leading to a …
Broad-spectrum anti-biofilm peptide that targets a cellular stress response
Bacteria form multicellular communities known as biofilms that cause two thirds of all
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …
Human commensals producing a novel antibiotic impair pathogen colonization
A Zipperer, MC Konnerth, C Laux, A Berscheid… - Nature, 2016 - nature.com
The vast majority of systemic bacterial infections are caused by facultative, often antibiotic-
resistant, pathogens colonizing human body surfaces. Nasal carriage of Staphylococcus …
resistant, pathogens colonizing human body surfaces. Nasal carriage of Staphylococcus …
Phenol-soluble modulins and staphylococcal infection
Staphylococcus aureus is an important human pathogen and a leading cause of death
worldwide. Phenol-soluble modulins (PSMs) have recently emerged as a novel toxin family …
worldwide. Phenol-soluble modulins (PSMs) have recently emerged as a novel toxin family …
Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
KL Tomlinson, TWF Lung, F Dach… - Nature …, 2021 - nature.com
Staphylococcus aureus is a prominent human pathogen that readily adapts to host immune
defenses. Here, we show that, in contrast to Gram-negative pathogens, S. aureus induces a …
defenses. Here, we show that, in contrast to Gram-negative pathogens, S. aureus induces a …
Phenol-soluble modulins–critical determinants of staphylococcal virulence
Phenol-soluble modulins (PSMs) are a recently discovered family of amphipathic, alpha-
helical peptides that have multiple roles in staphylococcal pathogenesis and contribute to a …
helical peptides that have multiple roles in staphylococcal pathogenesis and contribute to a …
Inside job: Staphylococcus aureus host-pathogen interactions
Staphylococcus aureus is a notorious opportunistic pathogen causing a plethora of
diseases. Recent research established that once phagocytosed by neutrophils and …
diseases. Recent research established that once phagocytosed by neutrophils and …