The acquisition of ligand‐independent ESR1 mutations during aromatase inhibitor therapy
in metastatic estrogen receptor (ER)‐positive breast cancer is a common mechanism of …

Approximately 70% of invasive breast cancers have some degree of dependence on the
estrogen hormone for cell proliferation and growth. These tumors have estrogen and/or …

Simple Summary Estrogens, belonging to a group of steroid compounds, play an important
role in both physiological and disease processes, mainly by interacting with estrogen …

Simple Summary Invasive lobular carcinoma (ILC), the second most common type of breast
cancer, is a distinct entity. Despite their unique biology and clinical course, lobular …

Somatic gain-of-function mutations within estrogen receptor alpha (ERα) are highly
associated with hormone therapy resistance in breast cancer. However, current …

The second most common breast carcinoma, invasive lobular carcinoma, accounts for
approximately 15% of tumors of breast origin. Its incidence has increased in recent times …