Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

This review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and
halogen RHS) on innate immunity. The importance of these species in innate immunity was …

Neutrophils represent the first line of cellular defense against invading microorganism by
rapidly moving across the blood–endothelial cell (EC) barrier and exerting effector cell …

At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

Rho GTPases are key regulators of cytoskeletal dynamics and affect many cellular
processes, including cell polarity, migration, vesicle trafficking and cytokinesis. These …

▪ Abstract Chemokines compose a sophisticated communication system used by all our cell
types, including immune cells. Chemokine messages are decoded by specific receptors that …

Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell
adhesion. The Rho GTPases play key roles in coordinating the cellular responses required …

Nitric oxide, nitric oxide derivatives and reactive oxygen intermediates are toxic molecules of
the immune system which contribute to the control of microbial pathogens and tumors. There …

Rho GTPases contribute to multiple cellular processes that could affect cancer progression,
including cytoskeletal dynamics, cell cycle progression, transcriptional regulation, cell …