Comparison of minimally invasive and traditional surgical approaches for refractory mesial temporal lobe epilepsy: a systematic review and meta‐analysis of …

K Kohlhase, JP Zöllner, N Tandon, A Strzelczyk… - …, 2021 - Wiley Online Library
Magnetic resonance‐guided laser interstitial laser therapy (MRgLITT) and radiofrequency
ablation (RFA) represent two minimally invasive methods for the treatment of drug‐refractory …

Magnetic resonance‐guided laser interstitial thermal therapy for drug‐resistant epilepsy: A systematic review and individual participant data meta‐analysis

JS Chen, AA Lamoureux, NA Shlobin, LM Elkaim… - …, 2023 - Wiley Online Library
Magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) has emerged as a
popular minimally invasive alternative to open resective surgery for drug‐resistant epilepsy …

Timing of referral to evaluate for epilepsy surgery: Expert Consensus Recommendations from the Surgical Therapies Commission of the International League Against …

L Jehi, N Jette, CS Kwon, CB Josephson… - …, 2022 - Wiley Online Library
Epilepsy surgery is the treatment of choice for patients with drug‐resistant seizures. A timely
evaluation for surgical candidacy can be life‐saving for patients who are identified as …

The interictal suppression hypothesis in focal epilepsy: network-level supporting evidence

GW Johnson, DJ Doss, VL Morgan, DL Paulo, LY Cai… - Brain, 2023 - academic.oup.com
Why are people with focal epilepsy not continuously having seizures? Previous neuronal
signalling work has implicated gamma-aminobutyric acid balance as integral to seizure …

The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy

RM Jamiolkowski, QA Nguyen, JS Farrell, RJ McGinn… - Nature Medicine, 2024 - nature.com
Targeted tissue ablation involving the anterior hippocampus is the standard of care for
patients with drug-resistant mesial temporal lobe epilepsy. However, a substantial …

Real‐world experience with direct brain‐responsive neurostimulation for focal onset seizures

B Razavi, VR Rao, C Lin, KA Bujarski, SE Patra… - …, 2020 - Wiley Online Library
Abstract Objective The RNS System is a direct brain‐responsive neurostimulation system
that is US Food and Drug Administration–approved for adults with medically intractable focal …

Temporal lobe epilepsy surgical outcomes can be inferred based on structural connectome hubs: a machine learning study

E Gleichgerrcht, SS Keller, DL Drane… - Annals of …, 2020 - Wiley Online Library
Objective Medial temporal lobe epilepsy (TLE) is the most common form of medication‐
resistant focal epilepsy in adults. Despite removal of medial temporal structures, more than …

Long-term outcomes of mesial temporal laser interstitial thermal therapy for drug-resistant epilepsy and subsequent surgery for seizure recurrence: a multi-centre …

BE Youngerman, MA Banu, F Khan… - Journal of Neurology …, 2023 - jnnp.bmj.com
Background Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a
minimally invasive alternative to surgical resection for drug-resistant mesial temporal lobe …

Magnetic resonance imaging-guided laser interstitial thermal therapy for epilepsy: systematic review of technique, indications, and outcomes

BE Youngerman, AV Save, GM McKhann - Neurosurgery, 2020 - journals.lww.com
BACKGROUND For patients with focal drug-resistant epilepsy (DRE), surgical resection of
the epileptogenic zone (EZ) may offer seizure freedom and benefits for quality of life. Yet …

Advances in therapy for refractory epilepsy

L Jehi - Annual Review of Medicine, 2024 - annualreviews.org
Drug-resistant epilepsy (DRE) is defined as failure to achieve sustained seizure control with
adequate trials of two appropriate antiseizure medications (ASMs). DRE affects one-third of …