Thyroid cancer: a review

L Boucai, M Zafereo, ME Cabanillas - Jama, 2024‏ - jamanetwork.com
Importance Approximately 43 720 new cases of thyroid carcinoma are expected to be
diagnosed in 2023 in the US. Five-year relative survival is approximately 98.5%. This review …

Thyroid cancer

DW Chen, BHH Lang, DSA McLeod, K Newbold… - The Lancet, 2023‏ - thelancet.com
The past 5–10 years have brought in a new era in the care of patients with thyroid cancer,
with the introduction of transformative diagnostic and management options. Several …

First-Line Selpercatinib or Chemotherapy and Pembrolizumab in RET Fusion–Positive NSCLC

C Zhou, B Solomon, HH Loong, K Park… - … England Journal of …, 2023‏ - Mass Medical Soc
Background Selpercatinib, a highly selective potent and brain-penetrant RET inhibitor, was
shown to have efficacy in patients with advanced RET fusion–positive non–small-cell lung …

Phase 3 Trial of Selpercatinib in Advanced RET-Mutant Medullary Thyroid Cancer

J Hadoux, R Elisei, MS Brose, AO Hoff… - … England Journal of …, 2023‏ - Mass Medical Soc
Background Selpercatinib, a highly selective, potent RET inhibitor, has shown efficacy in
advanced RET-mutant medullary thyroid cancer in a phase 1–2 trial, but its efficacy as …

Tumour-agnostic efficacy and safety of selpercatinib in patients with RET fusion-positive solid tumours other than lung or thyroid tumours (LIBRETTO-001): a phase 1/2 …

V Subbiah, J Wolf, B Konda, H Kang, A Spira… - The Lancet …, 2022‏ - thelancet.com
Background Selpercatinib is a first-in-class, highly selective RET kinase inhibitor with CNS
activity that has shown efficacy in RET fusion-positive lung and thyroid cancers. RET fusions …

Leveraging large language models for decision support in personalized oncology

M Benary, XD Wang, M Schmidt, D Soll… - JAMA Network …, 2023‏ - jamanetwork.com
Importance Clinical interpretation of complex biomarkers for precision oncology currently
requires manual investigations of previous studies and databases. Conversational large …

Thyroid carcinoma, version 2.2022, NCCN clinical practice guidelines in oncology

RI Haddad, L Bischoff, D Ball, V Bernet… - Journal of the National …, 2022‏ - jnccn.org
Differentiated thyroid carcinomas is associated with an excellent prognosis. The treatment of
choice for differentiated thyroid carcinoma is surgery, followed by radioactive iodine ablation …

[HTML][HTML] ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: a report from the ESMO Precision Medicine Working Group

J Pascual, G Attard, FC Bidard, G Curigliano… - Annals of …, 2022‏ - Elsevier
Circulating tumour DNA (ctDNA) assays conducted on plasma are rapidly develo** a
strong evidence base for use in patients with cancer. The European Society for Medical …

Overview of the 2022 WHO classification of neuroendocrine neoplasms

G Rindi, O Mete, S Uccella, O Basturk, S La Rosa… - Endocrine …, 2022‏ - Springer
In this review, we detail the changes and the relevant features that are applied to
neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and …

Selpercatinib in Patients With RET Fusion–Positive Non–Small-Cell Lung Cancer: Updated Safety and Efficacy From the Registrational LIBRETTO-001 Phase I/II Trial

A Drilon, V Subbiah, O Gautschi, P Tomasini… - Journal of Clinical …, 2023‏ - ascopubs.org
PURPOSE Selpercatinib, a first-in-class, highly selective, and potent CNS-active RET kinase
inhibitor, is currently approved for the treatment of patients with RET fusion–positive non …