Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …

Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …

Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …

A major rate-limiting step in develo** more effective immunotherapies for GBM is our
inadequate understanding of the cellular complexity and the molecular heterogeneity of …

The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer
progression in primary and metastatic brain malignancies. The unique properties of this …

Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers
with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs …

Microglia are resident immune cells in the central nervous system (CNS) that are capable of
carrying out prominent and various functions during development and adulthood under both …

Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of
multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a …