Cytosolic Ca 2+ concentration levels fluctuate in an ordered manner along the cell cycle, in
line with the fact that Ca 2+ is involved in the regulation of cell proliferation. Cell proliferation …

Contraction of smooth muscle is regulated by the cytosolic Ca2+ level ([Ca2+] i) b, and the
sensitivity to Ca2+ of the contractile elements in response to changes in the environment …

Many hormones, growth factors, and cytokines regulate proliferation of their target cells.
Perhaps the most universal signaling cascades required for proliferative responses are …

Pulmonary vascular medial hypertrophy caused by excessive pulmonary artery smooth
muscle cell (PASMC) proliferation is a major cause for the elevated pulmonary vascular …

BCL-2 is a 26-kDa integral membrane protein that represses apoptosis by an unknown
mechanism. Recent findings indicate that Ca2+ release from the endoplasmic reticulum …

Capacitative Ca2+ entry (CCE) through store-operated Ca2+ (SOC) channels plays an
important role in returning Ca2+ to the sarcoplasmic reticulum (SR) and regulating cytosolic …

Pulmonary arterial hypertension (PAH) is a severe and progressive disease that usually
culminates in right heart failure and death if left untreated. Although there have been …

▪ Abstract In many organs and tissues, the cellular response to injury is associated with a
reiteration of specific developmental processes. Studies have shown that, in response to …

A rise in cytosolic Ca2+ concentration ([Ca2+] cyt) due to Ca2+ release from intracellular
Ca2+ stores and Ca2+ influx through plasmalemmal Ca2+ channels plays a critical role in …

The impact of calcium signalling on so many areas of cell biology reflects the crucial role of
calcium signals in the control of diverse cellular functions. Despite the precision with which …