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Halophiles and their enzymes: negativity put to good use
Highlights•Halophiles produce stable enzymes that are active under high salt
conditions.•Halophilic enzymes maintain solvation and solubility in low water …
conditions.•Halophilic enzymes maintain solvation and solubility in low water …
Protein adaptations in archaeal extremophiles
CJ Reed, H Lewis, E Trejo, V Winston, C Evilia - Archaea, 2013 - Wiley Online Library
Extremophiles, especially those in Archaea, have a myriad of adaptations that keep their
cellular proteins stable and active under the extreme conditions in which they live. Rather …
cellular proteins stable and active under the extreme conditions in which they live. Rather …
Function and biotechnology of extremophilic enzymes in low water activity
Enzymes from extremophilic microorganisms usually catalyze chemical reactions in non-
standard conditions. Such conditions promote aggregation, precipitation, and denaturation …
standard conditions. Such conditions promote aggregation, precipitation, and denaturation …
Operative utility of salt-stable proteases of halophilic and halotolerant bacteria in the biotechnology sector
Proteases are universal in existence in all organisms and are needed for metabolic activities
of the cell. Also, proteases are the paramount hydrolytic enzymes widely used in industrial …
of the cell. Also, proteases are the paramount hydrolytic enzymes widely used in industrial …
Structural basis for the aminoacid composition of proteins from halophilic archea
Proteins from halophilic organisms, which live in extreme saline conditions, have evolved to
remain folded at very high ionic strengths. The surfaces of halophilic proteins show a biased …
remain folded at very high ionic strengths. The surfaces of halophilic proteins show a biased …
Extremely acidic proteomes and metabolic flexibility in bacteria and highly diversified archaea thriving in geothermal chaotropic brines
Few described archaeal, and fewer bacterial, lineages thrive under salt-saturating
conditions, such as solar saltern crystallizers (salinity above 30% w/v). They accumulate …
conditions, such as solar saltern crystallizers (salinity above 30% w/v). They accumulate …
Molecular bases of protein halotolerance
Halophilic proteins are stable and function at high salt concentration. Understanding how
these molecules maintain their fold stable and avoid aggregation under harsh conditions is …
these molecules maintain their fold stable and avoid aggregation under harsh conditions is …
Halophilic bacteria and their compatible solutes–osmoregulation and potential applications
Halophilic bacteria grow over an extended range of salt concentrations. Their metabolic
patterns are distinct compared to their terrestrial counterparts and obligate halophiles. The …
patterns are distinct compared to their terrestrial counterparts and obligate halophiles. The …
Biotechnological applications of halophilic lipases and thioesterases
Lipases and esterases are enzymes which hydrolyze ester bonds between a fatty acid
moiety and an esterified conjugate, such as a glycerol or phosphate. These enzymes have a …
moiety and an esterified conjugate, such as a glycerol or phosphate. These enzymes have a …
Halomonas elongata: a microbial source of highly stable enzymes for applied biotechnology
Extremophilic microorganisms, which are resistant to extreme levels of temperature, salinity,
pH, etc., have become popular tools for biotechnological applications. Due to their …
pH, etc., have become popular tools for biotechnological applications. Due to their …