The spectrum of malnutrition/cachexia/sarcopenia in oncology according to different cancer types and settings: a narrative review

P Bossi, P Delrio, A Mascheroni, M Zanetti - Nutrients, 2021 - mdpi.com
Nutritional status in oncological patients may differ according to several modifiable and non-
modifiable factors. Knowledge of the epidemiology of malnutrition/cachexia/sarcopenia may …

Cancer-associated cachexia—understanding the tumour macroenvironment and microenvironment to improve management

JM Argilés, FJ López-Soriano, B Stemmler… - Nature Reviews …, 2023 - nature.com
Cachexia is a devastating, multifactorial and often irreversible systemic syndrome
characterized by substantial weight loss (mainly of skeletal muscle and adipose tissue) that …

The role of tumor microenvironment cells in colorectal cancer (CRC) cachexia

A Kasprzak - International journal of molecular sciences, 2021 - mdpi.com
Cancer cachexia (CC) is a multifactorial syndrome in patients with advanced cancer
characterized by weight loss via skeletal-muscle and adipose-tissue atrophy, catabolic …

Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer

S Zheng, Y Zou, Y Tang, A Yang, JY Liang, L Wu… - …, 2022 - Taylor & Francis
Cancer-associated fibroblasts (CAFs) are essential for tumor microenvironment remodeling
and correlate with tumor progression. However, interactions between CAFs and tumor cells …

Redox tolerance and metabolic reprogramming in solid tumors

K Mortezaee - Cell Biology International, 2021 - Wiley Online Library
Tumor cells need to cope with the host environment for survival and keep growing in hard
conditions. This suggests that tumors must acquire characteristics more potent than what is …

Tumor-derived MMPs regulate cachexia in a Drosophila cancer model

W Lodge, M Zavortink, S Golenkina, F Froldi, C Dark… - Developmental Cell, 2021 - cell.com
Cachexia, the wasting syndrome commonly observed in advanced cancer patients,
accounts for up to one-third of cancer-related mortalities. We have established a Drosophila …

Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice

X Yang, J Wang, CY Chang, F Zhou, J Liu, H Xu… - Nature …, 2024 - nature.com
Cancer cachexia is a systemic metabolic syndrome characterized by involuntary weight loss,
and muscle and adipose tissue wasting. Mechanisms underlying cachexia remain poorly …

Cancer cachexia: lessons from Drosophila

Y Liu, P Saavedra, N Perrimon - Disease Models & …, 2022 - journals.biologists.com
Cachexia, a wasting syndrome that is often associated with cancer, is one of the primary
causes of death in cancer patients. Cancer cachexia occurs largely due to systemic …

Imaging modalities for diagnosis and monitoring of cancer cachexia

J Han, L Harrison, L Patzelt, M Wu, D Junker, S Herzig… - EJNMMI research, 2021 - Springer
Cachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage
cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight …

Cancer-associated muscle wasting—candidate mechanisms and molecular pathways

VS Armstrong, LW Fitzgerald, OF Bathe - International Journal of …, 2020 - mdpi.com
Excessive muscle loss is commonly observed in cancer patients and its association with
poor prognosis has been well-established. Cancer-associated sarcopenia differs from age …