Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics has undergone
dramatic developments over the past decade. This review focuses on state of the art in LC …

Type 1 and type 2 diabetes mellitus (DM) are chronic diseases that affect nearly 425 million
people worldwide, leading to poor health outcomes and high health care costs. High …

Mass spectrometry (MS)-based omics technologies are now widely used to profile small
molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …

Background: Inflammatory bowel disease [IBD] is considered to result from the interplay
between host and intestinal microbiota but its pathogenesis is incompletely understood …

Metabolomics, one of the 'omic'sciences in systems biology, is the global assessment and
validation of endogenous small-molecule metabolites within a biologic system. Analysis of …

Type 1 diabetes (T1D) is perceived as a progressive immune-mediated disease, the clinical
diagnosis of which is preceded by an asymptomatic preclinical period of highly variable …

Metabolomics is a promising “omics” field in systems biology; its objective is comprehensive
analysis of low-molecular-weight endogenous metabolites in a biological sample. It could …

Metabolomics is the systematic study of the unique chemical fingerprints of low molecular
weight endogenous metabolites or metabolite profiles in a biological sample. Metabolites …

Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …

There are three prerequisites for development of the autoimmune disease type 1 diabetes
(T1D). First, β cell-reactive T cells need to be activated; second, the response needs to be …