The pressure–temperature phase diagram of various biomolecules is reviewed. Special
attention is focused on the elliptic phase diagram of proteins. The phenomenological …

In his memorable book published in 1949, The Physics of High Pressure, 1 Bridgman states
that “it is a well-known result of thermodynamics that a substance is only completely …

Proteins can be denatured by pressures of a few hundred MPa. This finding apparently
contradicts the most widely used model of protein stability, where the formation of a …

The effect of pressure on the structure and dynamics of proteins is discussed in the
framework of the pressure-temperature stability phase diagram. The elastic (reversible) …

The effects of pressure on protein structure and function can vary dramatically depending on
the magnitude of the pressure, the reaction mechanism (in the case of enzymes), and the …

Compared to temperature, the development of pressure as a tool in the research field has
emerged only recently (at the end of the XIXth century). Following several developments in …

Hydrostatic pressure is a powerful tool for studying protein folding, and the dynamics and
structure of folding intermediates. Recently, pressure techniques have opened two important …

A theoretical approach is developed to quantify hydrophobic hydration and interactions on a
molecular scale, with the goal of insight into the molecular origins of hydrophobic effects …

Many commercially important shellfish are filter feeders and, as a consequence, concentrate
microbes from the surrounding waters. Shellfish may be relayed or depurated to reduce the …

In laboratories and manufacturing settings, a rapid and inexpensive method for the
preparation of a target protein is crucial for promoting resesrach in protein science and …