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Towards clinical utility of polygenic risk scores
Prediction of disease risk is an essential part of preventative medicine, often guiding clinical
management. Risk prediction typically includes risk factors such as age, sex, family history of …
management. Risk prediction typically includes risk factors such as age, sex, family history of …
Early diagnosis of Alzheimer's disease: the role of biomarkers including advanced EEG signal analysis. Report from the IFCN-sponsored panel of experts
Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly with a progressive decline in cognitive function significantly affecting quality of life …
elderly with a progressive decline in cognitive function significantly affecting quality of life …
Dementia in Latin America: paving the way toward a regional action plan
Abstract Across Latin American and Caribbean countries (LACs), the fight against dementia
faces pressing challenges, such as heterogeneity, diversity, political instability, and …
faces pressing challenges, such as heterogeneity, diversity, political instability, and …
The multi-partner consortium to expand dementia research in Latin America (ReDLat): driving multicentric research and implementation science
Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or
declining rates in North America and Europe. This scenario places unprecedented clinical …
declining rates in North America and Europe. This scenario places unprecedented clinical …
[HTML][HTML] Alzheimer disease overview
TD Bird - GeneReviews®[Internet], 2018 - ncbi.nlm.nih.gov
Alzheimer Disease Overview - GeneReviews® - NCBI Bookshelf US flag An official website of
the United States government Here's how you know NIH NLM Logo Access keys NCBI …
the United States government Here's how you know NIH NLM Logo Access keys NCBI …
Areas of uncertainties and unmet needs in bipolar disorders: clinical and research perspectives
This Review discusses crucial areas related to the identification, clinical presentation,
course, and therapeutic management of bipolar disorder, a major psychiatric illness. Bipolar …
course, and therapeutic management of bipolar disorder, a major psychiatric illness. Bipolar …
Polygenic risk scores in Alzheimer's disease genetics: methodology, applications, inclusion, and diversity
The success of genome-wide association studies (GWAS) completed in the last 15 years
has reinforced a key fact: polygenic architecture makes a substantial contribution to variation …
has reinforced a key fact: polygenic architecture makes a substantial contribution to variation …
Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment
Mild-cognitive impairment (MCI) occurs in up to one-fifth of individuals over the age of 65,
with approximately a third of MCI individuals converting to dementia in later life. There is a …
with approximately a third of MCI individuals converting to dementia in later life. There is a …
The Alzheimer's disease exposome
Introduction Environmental factors are poorly understood in the etiology of Alzheimer's
disease (AD) and related dementias. The importance of environmental factors in gene …
disease (AD) and related dementias. The importance of environmental factors in gene …
Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration
Mounting evidence indicates that the polygenic basis of late-onset Alzheimer's disease can
be harnessed to identify individuals at greatest risk for cognitive decline. We have previously …
be harnessed to identify individuals at greatest risk for cognitive decline. We have previously …