Already in the early 1960s, researchers noted the potential of mitochondria to take up large
amounts of Ca2+. However, the physiological role and the molecular identity of the …

Mitochondria are involved in multiple cellular tasks, such as ATP synthesis, metabolism,
metabolite and ion transport, regulation of apoptosis, inflammation, signaling, and …

Transport of molecules through biological membranes is a fundamental process in biology,
facilitated by selective channels and general pores. The architecture of some outer …

The voltage-dependent anion channel (VDAC), the most abundant protein in the outer
mitochondrial membrane, is responsible for the transport of all ions and metabolites into and …

The pro-apoptotic Bcl-2 protein Bax can permeabilize the outer mitochondrial membrane
and therefore commit human cells to apoptosis. Bax is regulated by constant translocation to …

Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …

Abstract Voltage-Dependent Anion selective Channels (VDAC) are pore-forming
mitochondrial outer membrane proteins. In mammals VDAC3, the least characterized …

We previously showed that the vitamin D receptor (VDR) plays a crucial role in acute
inflammatory bowel disease and that intestinal fibrosis is a common complication of Crohn's …

Intracellular organelles of mammalian cells communicate with one another during various
cellular processes. The functions and molecular mechanisms of such interorganelle …

In this mini-review, we analyze the influence of cysteines in the structure and activity of
mitochondrial outer membrane mammalian VDAC isoforms. The three VDAC isoforms show …