Polymeric delivery of therapeutic nucleic acids
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
Recent advances in nanomaterials for gene delivery—a review
MK Riley, W Vermerris - Nanomaterials, 2017 - mdpi.com
With the rapid development of nanotechnology in the recent decade, novel DNA and RNA
delivery systems for gene therapy have become available that can be used instead of viral …
delivery systems for gene therapy have become available that can be used instead of viral …
Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo
A family of pH-responsive diblock polymers composed of poly [(ethylene glycol)-b-[(2-
(dimethylamino) ethyl methacrylate)-co-(butyl methacrylate)], PEG-(DMAEMA-co-BMA), was …
(dimethylamino) ethyl methacrylate)-co-(butyl methacrylate)], PEG-(DMAEMA-co-BMA), was …
Nanoparticle interaction with biological membranes: does nanotechnology present a Janus face?
PR Leroueil, S Hong, A Mecke… - Accounts of chemical …, 2007 - ACS Publications
Polycationic organic nanoparticles are shown to disrupt model biological membranes and
living cell membranes at nanomolar concentrations. The degree of disruption is shown to be …
living cell membranes at nanomolar concentrations. The degree of disruption is shown to be …
PEI–PEG–chitosan‐copolymer‐coated iron oxide nanoparticles for safe gene delivery: synthesis, complexation, and transfection
Gene therapy offers the potential of mediating disease through modification of specific
cellular functions of target cells. However, effective transport of nucleic acids to target cells …
cellular functions of target cells. However, effective transport of nucleic acids to target cells …
Polymer systems for gene delivery—past, present, and future
SY Wong, JM Pelet, D Putnam - Progress in Polymer Science, 2007 - Elsevier
Gene therapy has long sought to treat disease by delivering therapeutic genes to diseased
cells. However, its widespread clinical use has faltered in the face of several challenges …
cells. However, its widespread clinical use has faltered in the face of several challenges …
Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style
S Zhu, M Hong, G Tang, L Qian, J Lin, Y Jiang, Y Pei - Biomaterials, 2010 - Elsevier
Partly PEGylated polyamidoamine (PAMAM) dendrimers were used as the carrier for tumor-
selective targeting of the anticancer drug doxorubicin (DOX). Acid-sensitive cis-aconityl …
selective targeting of the anticancer drug doxorubicin (DOX). Acid-sensitive cis-aconityl …
Influence of Polyethylene Glycol Chain Length on the Physicochemical and Biological Properties of Poly(ethylene imine)-graft-Poly(ethylene glycol) Block Copolymer …
Polyplexes between siRNA and poly (ethylene imine)(PEI) derivatives are promising
nonviral carriers for siRNA. The polyplex stability is of critical importance for efficient siRNA …
nonviral carriers for siRNA. The polyplex stability is of critical importance for efficient siRNA …
Biomimetic cell membrane-coated DNA nanoparticles for gene delivery to glioblastoma
Gene therapy has been introduced as an alternative to radiation and chemical therapy for
glioblastoma. Biomimetic nanoparticles coated with cell membranes (CM) have advantages …
glioblastoma. Biomimetic nanoparticles coated with cell membranes (CM) have advantages …